Substituted derivatives of octahydroindole-2-carboxylic acids

ABSTRACT

Compounds of the formula I ##STR1## in which n denotes 0-3, 
     R 1  and R 1&#39;   are the same or different and denote hydrogen, alkyl or alkenyl, phenyl or benzyl, each substituted as desired; 
     R 2  denotes hydrogen, alkyl or alkenyl; 
     R 3  denotes hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl or aminoalkyl, alkanoylaminoalkyl, guanidinoalkyl, imidazolylalkyl, indolylalkyl, mercaptoalkyl or alkylthioalkyl, phenylalkyl, hydroxyphenylalkyl, phenoxyalkyl or phenylthioalkyl, or R 2  and R 3 , together with the C and N atoms carrying them, denote a saturated or unsaturated 4- to 8-membered monocyclic or 8- to 10-membered bicyclic isocycle or heterocycle, optionally monosubstituted or disubstituted by hydroxyl, alkoxy having 1 to 3 C atoms or alkyl, 
     R 4  denotes hydrogen, alkyl, alkenyl, alkadienyl, alkinyl, alkeninyl or alkadiinyl, cycloalkyl, phenyl, benzyl, phenethyl or phenylpropyl, each of which can be optionally monosubstituted or disubstituted; 
     R 5  denotes hydrogen or alkyl, hydroxyl or alkoxy and 
     R 6  denotes hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, optionally monosubstituted or disubstituted phenyl or naphthyl, 
     their salts, a process for their preparation and their use as medicaments.

The invention relates to compounds of the formula (I) ##STR2## in which:n denotes a whole number between 0 and 3 inclusive, R¹ and R^(1'), beingthe same or different, denote hydrogen; alkyl or alkenyl having 1-8 Catoms; phenyl or benzyl, each substituted if desired by methyl, halogen,methoxy or nitro; R² denotes hydrogen, alkyl or alkenyl having 1-8 Catoms; R³ denotes hydrogen; alkyl having 1-10 C atoms; hydroxyalkyl,alkoxyalkyl or aminoalkyl each having 1-5 C atoms; alkanoylaminoalkylhaving 1-7 C atoms; guanidinoalkyl, imidazolylalkyl, indolylalkyl,mercaptoalkyl or alkylthioalkyl each having 1-6 alkyl C atoms;phenylalkyl having 1-5 alkyl C atoms; hydroxyphenylalkyl having 1-5alkyl C atoms; phenoxyalkyl or phenylthioalkyl each having 1-4 alkyl Catoms, or R² and R³ together with the C and N atoms carrying them form asaturated or unsaturated 4-8-membered monocyclic or 8-10-memberedbicyclic ring system, which contains 1-2 oxygen, 1-2 sulfur and/or 1-4nitrogen atoms and can be monosubstituted or disubstituted by hydroxyl,alkoxy having 1-3 C atoms, alkyl having 1-3 C atoms or phenyl; R⁴denotes hydrogen, alkyl, alkenyl, alkadienyl, alkinyl, alkeninyl oralkadiinyl having 1-8 C atoms, cycloalkyl having 3-6 C atoms; phenyl,benzyl, phenethyl or phenylpropyl, each of which can be monosubstitutedor disubstituted by halogen, hydroxyl, acetoxy, carboxy, carboxamido,sulfonamido, nitro, methyl, ethyl, methoxy, ethoxy or methylenedioxy; R⁵denotes hydrogen or alkyl having 1-5 C atoms, hydroxyl or alkoxy having1-3 C atoms; R⁶ denotes hydrogen; alkyl having 1-12 C atoms; cycloalkylhaving 3-12 C atoms; alkenyl having 1-12 C atoms; phenyl or naphthyl,each of which can be monosubstituted or disubstituted by halogen,hydroxyl, acetoxy, carboxy, carboxamido, sulfonamido, nitro, methyl,ethyl, methoxy, ethoxy or methylenedioxy; or alkyl having 1-6 C atoms,which is substituted by halogen, hydroxyl, alkoxy having 1-3 C atoms,phenoxy, amino, dialkylamino having 1-6 C atoms, alkanoylamino having1-3 C atoms, mercapto, alkylthio having 1-3 C atoms, phenylthio,phenylsulfinyl, phenylsulfonyl, phenyl, biphenylyl, naphthyl orheteroaryl, it being possible for the phenyl or naphthyl in turn to bemonosubstituted or disubstituted by halogen, methyl, ethyl, methoxy,ethoxy, nitro, amino, alkylamino, dialkylamino, acetylamino, cyano,methylenedioxy or sulfonamido and the heteroaryl to be substituted bythe substituents mentioned and additionally by phenyl, and their salts.

Compounds of the formula I are preferred in which the substituents havethe following meaning: n is 0 to 2, R¹ and R^(1') are hydrogen, alkyl oralkenyl having 1 to 4 C atoms, or benzyl optionally substituted in thephenyl nucleus by methyl, halogen, methoxy or nitro; R² is hydrogen,alkyl, alkenyl or alkinyl having 1 to 5 C atoms; R³ is the radical of anatural aminoacid, acetylaminobutyl, methoxymethyl, methoxyethyl,phenoxymethyl, methylthiomethyl, methylthioethyl or phenylthiomethyl; R²and R³ can be, together with the carbon or nitrogen atom carrying them,part of a saturated or unsaturated 4- to 8-membered monocyclic or 8- to10-membered bicyclic ring system, which, apart from carbon, can alsocontain an oxygen, sulfur and/or 1 to 3 nitrogen atoms in each case, andsuitable ring systems of this type are: as monocyclic systems,azetidine, dihydropyrrole, pyrrolidine, piperidine, the latter two beingoptionally monosubstituted or disubstituted by methoxy, ethoxy, methyl,ethyl or phenyl, hexahydroazepine, octahydroazocine, morpholine,N'-alkylpiperazine having 1 to 3 C atoms, N'-phenylpiperazine andthiazolidine, optionally substituted in the 2-position by methyl, ethyl,phenyl, hydroxyphenyl or methoxyphenyl, and as bicyclic systems,tetrahydroquinoline, tetrahydroisoquinoline, decahydroquinoline,decahydroisoquinoline, dihydroindole, octahydroindole,2-azabicyclo[3.3.0]octane, all of which being optionally monosubstitutedor disubstituted by methyl or methoxy,tetrahydroimidazolo[2,3-c]pyridine, tetrahydrothieno[2,3-c]pyridine,tetrahydrothieno[3,2-c]pyridine and tetrahydrothieno[3,4-c]pyridine; R⁴is hydrogen; straight-chain or branched alkyl, alkenyl or alkinyl having1 to 5 atoms; cycloalkyl, such as cyclopropyl, cyclobutyl, cyclopentyl,cyclohexyl; phenyl; benzyl or phenethyl; R⁵ is hydrogen, methyl, ethyl,hydroxyl, methoxy or benzyl; R⁶ is hydrogen, alkyl having 1 to 8 carbonatoms or phenyl which can be monosubstituted or disubstituted by methyl,halogen, methoxy, acetoxy or nitro; substituted alkyl having 1 to 4 Catoms, suitable substituents being: halogen, hydroxyl, methoxy, ethoxy,phenoxy, amino, methylamino, dimethylamino, anilino, acetylamino,benzamido, mercapto, phenylthio, phenylsulfinyl, phenylsulfonyl; phenylwhich is optionally monosubstituted or disubstituted by halogen, methyl,ethyl, methoxy, ethoxy, nitro, amino, methylamino, dimethylamino,acetylamino, cyano, methylenedioxy or sulfonamido; biphenylyl,heteroaryl, such as pyridyl, thienyl, indolyl, benzothienyl, imidazolyl,pyrazolyl and thiazolyl, optionally substituted by halogen, methyl,methoxy and phenyl.

Compounds of the formula (I) are particularly preferred in which thesubstituents have the following meaning: n is 0 or 1, R¹ and R^(1') arehydrogen, methyl, ethyl, n-butyl, t-butyl, benzyl or p-nitrophenyl, R²is hydrogen, methyl, ethyl or n-butyl, R³ is the radical of a naturalaminoacid or acetylaminobutyl, methoxymethyl, methoxyethyl,phenoxymethyl, methylthiomethyl, methylthioethyl or phenylthiomethyl; R²and R³ can be, together with the carbon or nitrogen atom carrying them,part of a saturated or unsaturated 5- to 7-membered monocyclic or 8- to10-membered bicyclic ring system which, apart from carbon, can alsocontain an oxygen or sulfur atom and/or 1 to 2 nitrogen atoms in eachcase, and suitable ring systems are: as monocyclic systems,dihydropyrrole; pyrrolidine, piperidine, the latter two being optionallysubstituted by methoxy, methyl or phenyl, hexahydroazepine,thiazolidine, optionally substituted in the 2-position by methyl, phenylor hydroxyphenyl, and as bicyclic systems, tetrahydroisoquinoline,decahydroisoquinoline, dihydroindole, octahydroindole,2-azabicyclo[3.3.0]octane, all optionally monosubstituted ordisubstituted by methyl or methoxy, tetrahydroimidazolo[2,3-c]pyridine,tetrahydrothieno[2,3-c]pyridine, tetrahydrothieno[3,2-c]pyridine andtetrahydrothieno[3,4-c]pyridine, R⁴ is methyl, ethyl, n-propyl, n-butyl,isopropyl, isobutyl, cyclopropyl, cyclobutyl, allyl, butenyl, propargyl,butinyl or tert.-butyl, R⁵ is hydrogen, methyl or benzyl, R⁶ ishydrogen, straight-chain or branched alkyl or alkenyl having 1 to 6 Catoms or cycloalkyl having 3 to 6 C atoms; substituted alkyl having 1 to3 C atoms, suitable substituents being: methoxy, ethoxy, phenoxy,dimethylamino, anilino, benzamido, phenylthio, phenylsulfinyl,phenylsulfonyl and phenyl optionally monosubstituted or disubstituted byhalogen, methyl, methoxy, nitro, amino, methylamino, dimethylamino,acetylamino, cyano or methylenedioxy; biphenylyl; heteroaryl, such aspyridyl, thienyl, indolyl, benzothienyl, imidazolyl or thiazolyl,optionally substituted by chlorine, methyl, methoxy or phenyl.

Special attention is drawn to compounds of the formula I in which n is1, R¹ denotes hydrogen, R² and R³, together with the C and N atomscarrying them, denote the 1,2,3,4-tetrahydroisoquinoline system, theoctahydroindole system or the 2-azabicyclo[3.3.0]octane system, R⁴denotes ethyl, R⁵ denotes hydrogen and R⁶ denotes β-phenylethyl.

The compounds of the formula I contain several asymmetric C atoms andthus they are in the form of enantiomers and diastereomers. Theinvention comprises the pure isomers and their mixtures. Those compoundsare preferred which have the S-configuration at the carbon atom whichcarries the substituent R³. Those compounds are particularly preferredwhich have the S-configuration at the carbon atom carrying thesubstitutent R³ and have the R configuration at that carrying theCOOR^(1') group. In compounds of the formula I, in which R² and R³,together with the C and N atoms carrying them, represent a saturatedbicyclic ring system with carbon atoms as bridgehead atoms, thecis-configuration with an endoorientation of the COOR¹ group relative tothe bicyclic ring system is preferred. Particularly preferred bicyclicring systems are endo-cis-octahydroindole andendo-cis-2-azabicyclo[3.3.0]octane.

The isomers can be prepared pure, for example by crystallization ofsuitable salts, such as the cyclohexylamine or dicyclohexylamine saltsor by chromatography on silica gel or ion exchangers. Where appropriate,the separations are carried out on suitable precursors.

If the compounds of the formula I have acid character, the inventioncomprises the free acids, their alkali metal and alkaline earth metalsalts and also the salts with pharmaceutically acceptable amines, suchas cyclohexylamine or dicyclohexylamine and basic aminoacids, such aslysine and arginine.

The invention further relates to a process for the preparation of thecompounds of the formula I. The process comprises reacting an aminoacidester of the formula II ##STR3## in which R⁷ has the same meaning as R¹,but is not hydrogen, with phosgene and then with a compound of theformula IV ##STR4## in which R⁸ has one of the meanings of R⁷, orreacting a compound of the formula IV with phosgene and then with acompound of the formula II, and, if appropriate, subjecting the productsobtained to hydrolysis.

In the process variant first mentioned, a compound of the formula II, inwhich R⁷ has the same meaning as R¹ in formula I, but is not hydrogen,is reacted with phosgene to give the N-chlorocarbonyl derivative of theformula (III). ##STR5##

In cases where R² denotes hydrogen, an isocyanate of the formula (III-a)can form in this reaction, particularly at an elevated temperature.##STR6##

The compound of the formula (III) or (III-a) is reacted with a compoundof the formula (IV) in which R⁸ has one of the meanings of R⁷ in formula(II) to give a compound of the formula (Ia). ##STR7##

In cases where R⁷ and R⁸ denote alkyl or phenyl, if desired, a compoundof the formula (I-a) can be hydrolyzed to give a compound of the formula(I-b). ##STR8##

If R⁷ in formula (I-a) denotes benzyl or 4-nitrobenzyl, a compound ofthe formula (I-a) can be converted into a compound of the formula (I-c)by hydrogenolysis. ##STR9##

The reaction of the compound of the formula (II) with phosgene iscarried out in an aprotic organic solvent, with or without the additionof an acidbinding agent; suitable acid-binding agents are basiccompounds, in particular organic nitrogen bases, for example,triethylamine, tripropylamine, N-methylmorpholine, pyridine and thelike. Examples of suitable solvents are methylene chloride, chloroform,tetrahydrofuran and dioxane. The reaction is carried out at atemperature which is low to slightly elevated, in general between -50°C. and +40° C., preferably at -30° C. to 0° C.

The reaction of a compound of the formula (III) with a compound of theformula (IV) is carried out under similar conditions but at a somewhathigher temperature, for instance 0° C. to 80° C., preferably 30° C. to50° C. Apart from the solvents mentioned, dimethylformamide is also verysuitable.

The reaction of a compound of the formula (IV) with an isocyanate of theformula (III-a) is carried out in a corresponding manner.

Hydrolysis of a compound of the formula (I-a) to give a compound of theformula (I-b) can be carried out by various means. In cases in which R⁷and R⁸ in formula (I-a) denote alkyl, but not t-butyl, the reaction canadvantageously be carried out with an alkali metal hydroxide orcarbonate in a mixture of water and a lower alcohol. A suitabletemperature is 0° C. to 100° C., preferably 20° C. to 40° C.

In cases in which R⁷ and R⁸ denote t-butyl, the reaction is carried outwith the aid of an acid, preferably a strong acid, such astrifluoroacetic acid, hydrochloric acid or sulfuric acid, without addinga solvent or in methanol or ethanol at 0° to 80° C., preferably at 20°C. to 40° C.

In cases in which either R⁷ or R⁸ denotes t-butyl and the other radicaldenotes alkyl or phenyl, the processes described above can also becarried out sequentially in any desired sequence. Catalytichydrogenolysis of a compound of the formula (I-a) wherein R⁷ denotesbenzyl or 4-nitrobenzyl can be brought about in a lower alcohol as thesolvent, with the addition of a catalyst.

Suitable catalysts for the hydrogenolysis are noble metal catalysts,such as palladium black, palladium on charcoal or platinum dioxide. Thereaction is carried out at a slightly elevated temperature, for instanceat 20° C. to 80° C., preferably at 20° C. to 40° C.. and under aslightly raised pressure of hydrogen, for instance 1 to 50 atmospheres,preferably under 1 to 8 atmospheres.

In analogy to the process indicated for the preparation of compounds ofthe formula (III), a compound of the formula (IV) can also be reactedwith phosgene to give a compound of the formula (V). ##STR10##

In cases where R⁴ denotes hydrogen, an isocyanate of the formula (V-a)##STR11## can be formed in this reaction, particularly at an elevatedtemperature.

A compound of the formula (V) or (V-a) is then reacted with a compoundof the formula (II) under the conditions described above for thepreparation of compounds of the formula (I-a) to give a compound of theformula (I-a).

The aminoacid esters of the formula (II) necessary as starting materialsfor this process are prepared from the corresponding aminoacids bycustomary methods (cf. the methods listed in Houben-Weyl/Muller,Methoden der Organischen Chemie (Methods of Organic Chemistry), volume15/1, pages 315-370). If the relevant aminoacids do not occur naturally,as a rule they are readily accessible by synthesis.

Hexahydroazepine-2-carboxylic acid and its highers homologs are obtainedfrom the lactam having the corresponding ring size by chlorination andFavorskii reaction with potassium tert.-butylate (J. Med. Chem. 14, 501(1971)).

Tetrahydroisoquinoline-3-carboxylic acid and its substituted derivativesare readily accessible by a Pictet-Spengler reaction from thecoresponding phenylalanine derivatives and formaldehyde (J. Amer. Chem.Soc. 70, 180 (1948)). Dihydroindole-2-carboxylic acid and itssubstituted derivatives are prepared in accordance with Aust. J. Chem.20, 1,935 (1967).

From the latter two, the corresponding decahydroisoquinoline andoctahydroindole derivatives respectively are obtained by hydrogenationunder pressure on a rhodium catalyst. Again using Pictet-Spenglercyclization with formaldehyde,tetrahydroimidazo[2,3-c]pyridinecarboxylic acid is obtained fromhistidine (Hoppe-Seyler's Z. physiol. Chem. 284, 131 (1949)) and thethienopyridine derivatives are obtained from the correspondingthienoalanines (Heterocycles 16, 35 (1981)).

Thiazolidine-5-carboxylic acids substituted in the 2-position are easilyobtained by a ring closure reaction from cysteine and the appropriatealdehyde (Japanese Pat. No. 5 5011-547).

The starting materials of the formula (IV-a) ##STR12## (corresponding toformula (IV) with n being O), are obtained by esterification of thecorresponding α-aminoacids under customary conditions (see above).Starting materials of the formula (IV-b) ##STR13## (corresponding toformula (IV) with n being 1), are obtained by addition of a primaryamine of the formula (VI)

    R.sup.4 -NH.sub.2                                          (VI)

to an α-alkylenecarboxylate of the formula (VII) ##STR14## Theα-alkylenecarboxylates of the formula (VII) are readily accessible fromthe corresponding alkylated malonic acid hemiesters of the formula(VIII) ##STR15## by Mannich reaction with formaldehyde and diethylamine(Arch. Pharm. 314, 197 (1981)).

The new compounds of the formula (I) have a long-lasting and stronghypotensive activity. This activity is developed by inhibition of theangiotensin converting enzyme (ACE). This enzyme converts thedecapeptide angiotensin I into the octapeptide angiotensin II which haspressor activity; dysregulation of this enzymic reaction is a factorwhich induces various forms of hypertension in mammals and humans.Furthermore, ACE inactivates, by degradation, bradykinin, which hasvasodepressor activity; this inactivation is also inhibited by the newcompounds. Various groups have recently described compounds which areeffective inhibitors of ACE (review, for example, J. Med. Chem. 24, 355(1981)). The new compounds compete advantageously with the inhibitorsdescribed therein. In vitro, they inhibit the converting enzyme withIC₅₀ values of 5×10⁻⁹ to 10⁻⁶ mole/1, and in vivo, on normotensive rats,the pressor reflex elicited by injection of angiotensin I is inhibitedlong-term by intravenous administration of doses at and above 0.1 mg/kg.

Because of these properties, the new compounds and their physiologicallytolerated salts can be used to control high blood pressure of variousetiologies by themselves or combined with other compounds which havehypotensive, vasodilator or diuretic activities. They can be used eitheralone or mixed with physiologically tolerated auxiliaries or vehicles.

The compounds can be administered orally or parenterally in anappropriate pharmaceutical formulation. For a form for oral use, theactive ccompounds are mixed with the additives customary for thispurpose, such as vehicles, stabilizers or inert diluents and convertedby customary methods into suitable forms for administration, such astablets, coated tablets, hard capsules, aqueous-alcoholic or oilysuspensions or aqueous-alcoholic or oily solutions. Inert excipientswhich can be used are, for example, gum arabic, magnesium carbonate,potassium phosphate, lactose, glucose or starch, in particular cornstarch. For this purpose, formulation can be as dry or as moistgranules. Examples of suitable oily vehicles or solvents are plant andanimal oils, such as sunflower oil or cod-liver oil.

For subcutaneous or intravenous administration, the active compounds ortheir physiologically tolerated salts are converted as desired, with thesubstances customary for this purpose, such as solubilizers, emulsifiersor other auxiliaries, into solutions, suspensions or emulsions. Examplesof suitable solvents for the new active compounds and the correspondingphysiologically tolerated salts are: water, physiological saline oralcohols, for example ethanol, propaneidiol or glycerol, in additionsugar solutions, such as glucose or mannitol solutions, and also amixture of the various solvents mentioned.

The daily dose for compounds of the formula (I) and their salts is 20 mgto 3 g, preferably 50 mg to 1 g per patient. No toxic effects of thesubstances have been observed hitherto.

Unless another process is indicated, the compounds described in thefollowing Examples were subjected to HPLC purification for analysis andbiological determination.

Since all the compounds according to the invention have been prepared byonly two methods, these two processes are to be presented in detail infour Examples in the following text. The other derivatives preparedanalogously are compiled in a Table with their NMR data.

EXAMPLE 1(3S)-<N-Isopropyl-N-(4-phenyl-2-carboethoxybutyl)carbamoyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid

1.1. Benzyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylatebenzenesulfonate

53 g (0.3 mole) of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, 150ml of benzyl alcohol and 53.3 g (0.33 mole) of benzenesulfonic acid wereheated at 140° C. for 1 hour, then 100 ml of toluene were added and themixture was boiled under a water separator until the theoretical amountof water had formed. Thereafter, the solvent was removed, the residuewas digested with ether, the precipitate was filtered off with suctionand recrystallized from ethanol/ether.

Melting point 165°-166° C.

[α]_(D) -42.1°, c=1 (DMF)

1.2. BenzylN-chlorocarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

4.25 g of the above benzyl ester benzenesulfonate were dissolved in 100ml of saturated sodium bicarbonate solution and this was extracted withmethylene chloride, dried over sodium sulfate and the solvent wasremoved. The residue (2.67 g/0.01 mole) was dissolved, together with 1.5g (0.015 mole) of triethylamine, in 10 ml of dry methylene chloride. Thesolution was added dropwise at -20° to -30° C. to 11.5 ml of a 15%strength solution of phosgene in methylene chloride, the mixture wasstirred for 30 minutes and then evaporated to dryness.

1.3 Diethyl phenethylmalonate

45 g of diethyl malonate and 30 g of phenethyl bromide were mixed andadded dropwise, cooling in ice, to a solution of sodium ethylateprepared from 6.5 g of sodium and 130 ml of absolute ethanol. Themixture was then boiled under reflux for 6 hours and allowed to cooldown overnight. The major part of the ethanol was removed in vacuo, theresidue was taken up in water, extracted with ether, this was dried overNa₂ SO₄, evaporated and distilled.

Boiling point₀.1 90° C.

1.4. Ethyl 2-methylene-4-phenylbutyrate

26.6 g (0.1 mole) of diethyl phenethylmalonate were added dropwise inthe course of an hour, with stirring, to 5.6 g of KOH in 65 ml ofabsolute ethanol, the mixture was stirred at room temperature for 15hours and then boiled for 5 minutes. The ethanol was removed in vacuo,ice-water was added and the mixture was extracted with ether. Theaqueous phase was acidified with 2N hydrochloric acid and extracted withether. The second extract was dried and evaporated and then neutralizedwith 8.8 ml of diethylamine. 12 ml of 30% strength formaldehyde solutionwere added, the mixture was stirred for 3 hours, then saturated withpotassium carbonate, extracted with ether, the extract was washed withdilute hydrochloric acid, dried and evaporated.

NMR (CDCl₃)δ=7.05 s (5H); 6.02 s (1H); 5.4 s (1H); 4.15 q (4H); 2.65 bs(4H); 1.25 t (3H).

1.5. N-Isopropyl-N-(2-carboethoxy-4-phenylbutyl)amine

14.2 g of ethyl 2-methylene 4-phenylbutyrate and 5.7 ml ofisopropylamine were stirred in 25 ml of absolute ethanol at roomtemperature for 12 days, the solvent was removed, the residue was takenup in 1N hydrochloric acid, extracted with ether and the aqueous phasewas made alkaline with sodium carbonate, extracted with ether and thiswas dried and evaporated.

NMR (CDCl₃): δ=7.1 s (5H), 4.1 q (2H); 3.0-2.2 m (6H); 2.05-1.5 m (3H);1.22 t (3H); 1.0 d (6H).

1.6. Benzyl(3S)-<N-isopropyl-N-(4-phenyl-2-carboethoxybutyl)-carbamoyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylate.

The crude benzylN-chlorocarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (from 1.2)was taken up in 10 ml of CH₂ Cl₂, a solution of 2.6 g ofN-isopropyl-N-(2-carboethoxy-4-phenylbutyl)amine and 1.2 ml oftriethylamine in 10 ml of methylene chloride were added dropwise and themixture was heated at 35° C. for 20 hours, then evaporated to dryness,the residue was taken up in ethyl acetate, the solution was washed with1N hydrochloric acid, saturated sodium bicarbonate solution and water,dried and evaporated. The crude product was separated into the twodiastereomers of the product on silica gel. Isomer 1: NMR: (CDCl₃)δ7.3-6.8 m (14H); 5.05 s+t(3H); 4.48 s (2H), 4.2-3.5 m (4H); 3.4-2.4 m(6H); 2.0-1.6 m (2H); 1.3-0.9 m (9H).

Isomer 2: NMR (CDCl₃) δ7.3-6.9 m (14H); 5.0 s (2H); 4.8 t (1H); 4.52 s(2H); 4.2-3.5 m (4H); 3.3-2.4 m (6H); 2.0-1.6 m (2H); 1.3-1.0 m (9H).

1.7.(3S)-<N-Isopropyl-N-(4-phenyl-2-carboethoxybutyl)-carbamoyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid

1.7.1. Isomer 1

1.35 g of 1.6 (isomer 1) were hydrogenated in 30 ml of absolute ethanolwith 0.7 g of Pd/C (10% strength) under 1 atmosphere pressure ofhydrogen for 4 hours. After completion of uptake of hydrogen, themixture was filtered and evaporated.

NMR δ=7.4-6.9 m (9H); 6.5 bs (1H); 4.66 t (1H); 4.4 s (2H); 4.2-3.5 m(3H); 3.4-2.3 m (7H); 2.0-1.6 m (2H); 1.3-0.9 m (9H).

Sodium salt: 0.35 g of 1.7.1. was taken up in 10 ml of H₂ O, heated with63 mg of sodium bicarbonate for 30 minutes, the mixture was evaporatedand solidified with ether; colorless powder.

IR 1730, 1620 cm⁻¹

1.7.2 Isomer 2

1.62 g of 1.6 (isomer 2) were hydrogenated in 30 ml of absolute ethanolwith 0.7 g of Pd/C (10% strength) under 1 atmosphere pressure ofhydrogen for 1.5 hours. After completion of uptake of hydrogen, themixture was filtered and evaporated.

NMR=δ7.3-6.9 m (9H); 5.1 bs (1H); 4.60 t (1H); 4.30 s (2H); 4.2-3.5 m(3H); 3.3-2.4 m (7H); 2.0-1.5 m (2H); 1.4-1.0 m (9H).

Lysine salt: 0.57 g of 1.7.2. was dissolved in 10 ml of methanol, 0.21 gof lysine in 5 ml of water were added, the mixture was evaporated todryness and solidified with ether, colorless powder.

IR 1730, 1610 cm⁻¹

EXAMPLE 2(3S)-<N-Isopropyl-N-(4-phenyl-2-carboxybutyl)-carbamoyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid

2.1. Isomer 1

0.55 g of 1.7.1 was dissolved in 6 ml of ethanol, 6 ml of 6N sodiumhydroxide solution were added and the mixture was allowed to standovernight, the ethanol was removed, the residue was acidified with 1Nhydrochloric acid, extracted with methylene chloride and this was driedover magnesium sulfate, evaporated and the residue was crystallized fromchloroform/petroleum ether.

Melting point 118°-120° C.

NMR (DMSO)=δ7.1 s (9H); 4.5 t (1H); 4.43 s (2H); 4.0-2.8 m (7H); 1.9-1.5m (2H), 1.05 dd (6H).

2.2 Isomer 2

0.68 g of 1.7.2 was dissolved in 10 ml of ethanol, 10 ml of 6N sodiumhydroxide solution were added and the mixture was stirred for 2 hours,the ethanol was removed, the residue was acidified with 1N hydrochloricacid, extracted with methylene chloride, and this was dried andevaporated to a colorless foam.

NMR (CDCl₃)=δ7.0 s (9H); 4.65 t (1H); 4.44 s (2H); 4.0-3.0 m (7H),2.1-1.6 m (2H); 1.1 dd (6H).

Bisdicyclohexylamine salt: 0.65 g of 2.2 was dissolved in 10 ml ofmethylene chloride, 0.6 ml of dicyclohexylamine was added, the mixturewas evaporated and the residue was triturated with n-hexane; colorlesscrystals.

Melting point 67°-70° C. (decomposition).

IR 1630 cm⁻¹

EXAMPLE 3(3S)-<N-Methyl-N-(4-phenyl-2-carboethoxybutyl)-carbamoyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid

3.1. N-Methyl-N-(2-carboethoxy-4-phenylbutyl)amine

26.3 g of ethyl 2-methylene-4-phenylbutyrate (1.4) and 4 g ofmethylamine in 150 ml of ethanol in an autoclave were heated at 80° C.for 10 hours. After cooling down, the ethanol was removed, the residuewas taken up in 1N HCl, this was extracted with ether, made alkalinewith sodium carbonate and again extracted, dried and evaporated.

NMR (CDCl₃)=7.1 s (5H); 4.1 q (2H); 3.1 s (3H); 3.0-2.2 m (6H); 2.0-1.5m (2H); 1.22 t (3H).

3.2 N-Methyl-N-chlorocarbonyl-N-(2-carboethoxy-4-phenylbutyl)amine

2.35 g of 3.1 were dissolved in 10 ml of dry methylene chloride togetherwith 1.5 g of triethylamine. This solution was added dropwise to 11.5 mlof a 15% strength solution of phosgene in methylene chloride at -20° to-30° C., the mixture was stirred for 30 minutes and then evaporated todryness.

3.3. 2-Carbobenzoxy-3-carboxy-1,2,3,4-tetrahydroisoquinoline (Z-Tiq)

188 g (1.05 moles) of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acidwere added to 1,050 ml of 1N NaOH at 0° and then at this temperature,100 ml of benzyl chlorocarbonate and a further 1,050 ml of 1N NaOH wereadded dropwise simultaneously. The mixture was then stirred at roomtemperature for 2 hours, then extracted three times with ether andacidified with concentrated HCl to pH 1. The oil which separated out wasextracted into ethyl acetate. The ethyl acetate solution was washed withwater until the water phase had a pH of 3. After drying, the productcrystallized on evaporation and scratching. 1.5 liters of diisopropylether were added and the mixture was stirred at room temperature for onehour. The product was then filtered off with suction; melting point138°-139°.

3.4 Tert.-butyl ester of2-carbobenzoxy-3-carboxy-1,2,3,4-tetrahydroisoquinoline

312 ml of tert.-butanol and 8 g of 4-dimethylaminopyridine were added toa solution of 248.8 g (0.8 mole) of 3.3 in 1.6 liters of methylenechloride. The mixture was cooled down to -5° C. and a solution of 176 gof dicyclohexylcarbodiimide in 350 ml of methylene chloride was added inportions. After 21 hours at room temperature, the precipitateddicyclohexylurea was filtered off with suction. The filtrate wasextracted three times with saturated sodium bicarbonate solution. Theorganic phase was dried over magnesium sulfate and evaporated in vacuoat room temperature. A yellowish oil remained.

NMR: 7.3 s (5H); 7.2 s (4H); 5.1-4.3 m (3H); 5.0 s (2H); 1.46 s (9H).

3.5. Tert.-butyl ester of 3-carboxy-1,2,3,4-tetrahydroisoquinolinehydrochloride

284 g of 3.4 (0.775 mole) were dissoved in 3 liters of methanol, 15 g of10% Pd-barium sulfate catalyst were added and the mixture washydrogenated with hydrogen under normal pressure. The pH was maintainedat 4.0 by dropwise addition of 1N methanolic HCl. When the uptake ofhydrogen was complete, the mixture was filtered with suction, thefiltrate was evaporated and the residue triturated with ether.

Melting point 180° C. (decomposition)

3.6. Tert.-butyl(3S)-<N-methyl-N-(4-phenyl-2-carboethoxybutyl)-carbamoyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

2.7 g of 3.5 were dissolved in 30 ml of saturated sodium bicarbonatesolution, the solution was extracted with methylene chloride and theextract was dried and evaporated. The residue was dissolved in 10 ml ofmethylene chloride and 1.2 g of triethylamine and added dropwise to 3.2.in 10 ml of methylene chloride. The mixture was warmed at 35° C. for 20hours, then evaporated to dryness and the residue was taken up in ethylacetate, washed with saturated sodium bicarbonate solution, 1N HCl andwater, dried over magnesium sulfate and evaporated; pale yellow resin.

NMR: 7.3-6.8 m (14H); 5.0 s (2H); 5.0-4.8 m (1H); 4.5 s (2H); 4.2-3.5 m(3H); 3.0 s (3H); 3.3-2.4 m (6H); 2.0-1.6 m (2H); 1.1 t (3H).

3.7.(3S)-<N-methyl-N-(2-carboethoxy-4-phenylbutyl)carbamoyl>-1,2,3,4tetrahydroisoquinoline-3-carboxylicacid

3 g of 3.6. were stirred with 40 ml of trifluoroacetic acid at roomtemperature for 2 hours and then evaporated to dryness. The residue wastaken up in ethyl acetate, washed three times with water, dried andevaporated.

NMR 7.4-6.9 m (9H); 6.8 bs (1H); 4.6 t (1H); 4.4 s (2H); 4.2-3.5 m (2H);3.4-2.3 m (7H); 3.0 s (3H); 2.0-1.6 m (2H); 1.1 t (3H)

Lysine salt: colorless powder

IR 1730, 1610 cm⁻¹

EXAMPLE 4(3S)-<N-Methyl-N-(2-carboxy-4-phenylbutyl)-carbamoyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid

1.3 g of 3.7. were dissolved in 20 ml of ethanol, 20 ml of 6 N sodiumhydroxide solution were added, the mixture was stirred at roomtemperature for 3 hours, the ethanol was removed in vacuo and theresidue was acidified with 1N hydrochloric acid, extracted withmethylene chloride and dried over magnesium sulfate, and thenevaporated.

NMR 7.6-6.9 m (9H); 6.0 bs (2H); 4.6 t (1H); 4.4 s (2H); 3.4-2.3 m (7H);3.0 s (3H); 2.0-1.6 m (2H).

EXAMPLE 5(3S)-<N-Ethyl-N-(4-phenyl-2R-carboethoxybutyl)-carbamoyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid

5.1. N-Ethyl-N-(2-carboethoxy-4-phenylbutyl)amine

17 g of ethyl 2-methylene-4-phenylbutyrate (Example 1.4) and 3.6 g ofethylamine were dissolved in 50 ml of absolute ethanol and heated under40 atmospheres of nitrogen at 105° C. for 20 hours. After the solventhad been removed, the residue was taken up in 5 normal hydrochloricacid, extracted with ether and the aqueous solution was adjusted to pH9.5 with potassium carbonate, again extracted with ether, and this wasdried with potassium carbonate and evaporated.

NMR (CDCl₃): 7.1 s (5H); 4.1 q (2H); 3.0-2.2 m (6H); 2.0-1.4 m (2H); 1.1d+t (6 H).

5.2. Benzyl(3S)-<N-ethyl-N-(4-phenyl-2-carboethexybutyl-carbamoyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

4.25 g of benzyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylatebenzenesulfonate were reacted with phosgene and 2.5 g ofN-ethyl-N-(carboethoxy-4-phenylbutyl)amine by the process described inExample 1.2. and 1.6. After chromatography on silica gel (eluting withethyl acetate/cyclohexane 1:5), 1.99 g of isomer 1 and 2.45 g of isomer2 were obtained.

Isomer 1: NMR (CDCl₃) 7.3-6.8 m (14H); 5.05 s (2H); 4.95 t (1H); 4.48 s(2H); 4.2-3.5 m (4H); 3.4-2.4 m (6H); 2.0-1.6 m (3H); 1.1 t (6H);

Isomer 2: NMR (CDCl₃) 7.3-6.8 m (14H); 5.05 s (2H); 4.82 t (1H); 4.4 s(2H); 4.2-3.5 m (4H); 3.4-2.4 m (6H); 2.0-1.5 m (3H); 1.1 t (6H)

5.3.(3S)-<N-Ethyl-N-(4-phenyl-2R-carboethoxybutyl)carbamoyl>-1,2,3,4,-tetrahydroisoquinoline-3-carboxylicacid 1.9 g of isomer 1 from Example 5.2. were hydrogenated by theprocess described in Example 1.7.

1H-NMR 7.4-6.9 m (9H); 6.5 bs (1H); 4.6 t (1H); 4.4 s (2H); 4.2-3.5 m(3H); 3.4-2.3 m (6H); 2.0-1.6 m (2H); 1.3-0.9 m (6H).

Lysine salt: 0.87 g of 5.3 was dissolved in 10 ml of methanol and 0.28 gof lysine in 5 ml of water was added. The solvent was removed and theresidue was triturated with ether; colorless power.

EXAMPLE 6(2R)-<N-Ethyl-N-(4-phenyl-2S-carboethoxybutyl)-carbamoyl>-cis-endo-octahydroindole-2-carboxylicacid

6.1. Benzyl (2S)-cis-endo-octahydroindole-2-carboxylate hydrochloride

3 g of (2S)-cis-endo-octahydroindole-2-carboxylic acid (preparedaccording to European Patent application No. 37,231) were added to asolution of 3 ml of thionyl chloride in 28.5 ml of benzyl alcoholprepared at -10° C. After 15 hours, the benzyl alcohol was distilled offand the product was triturated with diisopropyl ether, melting point140° C.

6.2. Benzyl(2S)-<N-ethyl-N-(4-phenyl-2-carboethoxybutyl)-carbamoyl>-cis-endo-octahydroindole-2-carboxylate

2.96 g of the compound from Example 6.1 were reacted with phosgene and2.5 g of the compound from Example 5.1 in accordance with the processdescribed in Example 1.2 and 1.6. Separation of the diastereomers wascarried out on silica gel using ethyl acetate/cyclohexane 1:4 as theeluant.

Isomer 1: [α]_(D) ²⁰ +7.0° (c=1, CH₃ OH); ¹ H-NMR (CDCl₃) 7.3 s (5H);7.2 s (5H); 5.2-4.7 m (3H); 4.1 q (2H); 3.9-1.4 m (20H); 1.2 t (3H); 1.0t (3H).

Isomer 2: [α]_(D) ²⁰⁻ 4.6° C. (c=1, CH₃ OH); ¹ H-NMR (CDCl₃): 7.3 s(5H); 7.15 s (5H); 5.1 s (2H); 5.0-4.6 m (1H); 4.1 q (2H); 3.9-1.4 m(20H); 1.2 t (3H); 1.0 t (3H).

6.3.(2R)-<N-Ethyl-N-(4-phenyl-2S-carboethoxybutyl)-carbomoyl>-cis-endo-octanhydroindole-2-carboxylicacid

1.5 g of the isomer 1 from Example 6.2 were hydrogenated by the processdescribed in Example 1.7.

[α]_(D) ²⁰ + 23.3° (c=1, CH₃ OH).

¹ H-NMR (CDCl₃) 7.15 s (5H); 4.5 m (1H); 4.1 q (2H); 3.9-1.4 m (20H);1.0 t (6H).

Sodium salt: 0.876 g of 6.3 was dissolved in 10 ml of ethanol, 1.9 ml of1N sodium hydroxide solution were added. The mixture was evaporated andtriturated with ether; colorless powder.

EXAMPLE 7(3S)-<N-Ethyl-N-(4-phenyl-2R-carboxybutyl)-carbomoyl>-1,2,3,4tetrahydroisoquinoline-3-carboxylicacid

0.72 g of the compound from Example 5.3 was saponified with 10 ml of 6Nsodium hydroxide solutionby the process described in Example 2.

¹ H-NMR: 7.1 s (9H); 4.5 t (1H); 4.4 s (2H); 4.0-2.8 m (8H); 1.9-1.5 m(2H); 1.05 t (3H).

EXAMPLE 8(2R)-<N-Ethyl-N-(4-phenyl-2S-carboxybutyl)-carbamoyl>-cis-endo-octahydroindole-2-carboxylicacid

0.39 g of the compound from Example 6.3 was saponified with sodiumhydroxide solution by the process described in Example 2.

[α]_(D) ²⁰ + 15.8° (c=1, CH₃ OH).

¹ H-NMR (CDCl₃) 7.15 s (5H); 4.5 m (1H); 3.9-m (20H); 1.0 t (3H).

Bisdicyclohexylamine salt: 0.31 g was dissolved in 10 ml of methylenechloride, 0.29 ml of dicyclohexylamine was added, the mixture wasevaporated and triturated with diisopropyl ether; colorless powder.

EXAMPLE 9<N-Ethyl-N-(4-phenyl-2-carboethoxybuyl)-carbamoyl>-cis-endo-2-azabicyclo[3.3.0]octane-3-carboxylicacid

9.1. Benzyl cis-endo-2-azabicyclo[3,3,0]octane-3-carboxylatehydrochloride

Prepared from cis-endo-2-azabicyclo[3.3.0]octane-3-carboxylic acid bythe process described in Example 6.1.

9.2. Benzyl<N-ethyl-N-(4-phenyl-2-carboethoxybutyl)carbamoyl>-cis-endo-2-azabicyclo[3.3.0]octane-3-carboxylate

2.82 g of the compound from Example 9.1 were reacted with phosgene and2.5 g of the compound from Example 5.1 by the processes described inExample 1.2 and 1.6. Separation of the diastercomers was carried out onsilica gel using ethyl acetate/cyclohexane (1:3) as eluant.

Isomer 1 ¹ H-NMR (CDCl₃): 7.3 s (5H); 7.2 s (5H); 5.3-4.7 m (3H); 4.1 q(2H); 3.9-1.4 m (18H); 1.2 t (3H); 1.05 t (3H).

Isomer 2 ¹ H-NMR (CDCl₃): 7.3 s (5H); 7.15 s (5H); 5.1 s (2H); 4.8 m(1H); 4.15 q (2H); 4.0-1.5 m (18H); 1.15 t (3H); 1.0 t (3H).

9.3.<N-Ethyl-N-(4-phenyl-2-carboethoxybutyl)-carbamoyl>-cis-endo-2-azabicyclo[3.3.0]octane-3-carboxylicacid

Prepared from 1 g of isomer 2 from Example 9.2 by the process describedin Example 6.2.

¹ H-NMR (CDCl₃) 7.1 s (5H); 4.4 m (1H); 4.1 q (2H); 3.8-1.4 m (18H); 1.0t (6H).

EXAMPLE 10<N-Ethyl-N-(4-phenyl-2-carboxybutyl)-carbomoyl>-cis-endo-2-azabicyclo[3.3.0]octane-3-carboxylicacid

Prepared from 0.32 g of the compound from Example 9.3 by the processdescribed in Example 5.3.

¹ H-NMR (CDCl₃) 7.1 s (5H); 4.5 m (1H); 3.8-1.4 m (18H); 1.0 t (3H).

The compounds listed in the following table were prepared by analogousprocesses using the appropriate starting materials.

      ##STR16##       n R.sup.1 R.sup.1      ' R.sup.2 R.sup.3 R.sup.4 R.sup.5 R.sup.6               11 0 H H H     CH.sub.3 CH.sub.3 -- CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H);     4.7-4,4 m (1H); 3.8-2.8 m          (3H); 3.0 2 s (3H); 2.0-1.7 m (2H);            1.2 d (5H) 12 1 H H H CH.sub.3 C.sub.2 H.sub.5 H CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.4 m (1H); 3.5-2.8 m     (7H); 2.0-1.7 m (2H); 1.2 d + t (6H) 13 1 H C.sub.2 H.sub.5 H CH.sub.3     C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.4     m (1H); 4.2 q (2H)          3.5-2.8 m (7H); 2.0-1.7 m (2H); 1.2 d       + t (9H) 14 1 H H H (CH.sub.3).sub.2 CH CH.sub.3 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.44-OCH.sub.3 7.0-6.5 m (4H); 4.8-4.4 m (1H);     3.5-2.8 m (5H); 3.0 2 s (3H);          1.9-1.3 m (3H); 1.2-0.9 d (6H) 15     0 H H H (CH.sub.3).sub.2 CH C.sub.2 H.sub.5 -- CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 7.2 s (5H); 4.8-4.3 m (2H); 3.8-2.9 m          (2H); 2.8-2.0 m     (2H); 1.8-1.3 m (3H);          1.3- 0.9 m (9H) 16 0 H C.sub.2 H.sub.5 H     (CH.sub.3).sub.2 CH C.sub.2 H.sub.5 -- CH.sub.2 CH.sub.2 C.sub.6 H.sub.5     7.2 s (5H); 4.8-4.3 m (2H); 4.1 q (2H)          3.9-2.9 m (2H); 2.8-2.0     m (2H);         1.8-1.3 m (3H); 1.3-0.9 m (12H) 17 1 H H CH.sub.3     (CH.sub.3).sub.2 CH CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 7.2 s (5H); 4.7-4.4 m (1H); 3.8-2.8 m          (4H); 3.0 s (3H);     2.0-1.7 m (2H);          1.6-1.3 m (3H); 1.2-0.9 m (12H)  18 1 H H H     (CH.sub.3).sub.2      CHCH.sub.2     ##STR17##      H CH.sub.2 CH.sub.2C.sub.6 H.sub.44-F 7.2-6.9 m (4H); 4.7-4.4 m (1H);     3.8-2.6 m (4H); 2.8-2.0 m (2H); 1.9-1.4 m(5H); 1.2-0.6 m (10H)  19 1 H     C.sub.2 H.sub.5 H (CH.sub.3).sub.2      CHCH.sub.2     ##STR18##      H CH.sub.2CH.sub.2C.sub.6 H.sub.44-F 7.2-6.9 m (4H); 4.7-4.4 m (1H);     4.2 q(2H) 3.8-2.6 m (4H); 2.8-2.0 m (2H);1.9-1.4 m (5H); 1.2-0.6 m + t     (13H)  20 1 H H CH.sub.3 (CH.sub.3).sub.2 CHCH.sub.2 HCCCH.sub.2 H     CH.sub.2 CH.sub.2C.sub.6 H.sub.3(OCH.sub.3).sub.23,4 6.8-6.4 m (3H);     4.7-4.4 m (1H);           3.8-2.6 m (5H); 3.9 s (6H); 3.0 s     (3H); 2.8-2.0 m (2H); 1.9-1.4 m (6H);          1.1-0.9 m (6H) 21 0 H H H     (CH.sub.3).sub.2 CHCH.sub.2 CH.sub.3 CH.sub.2      CH.sub.2 -- CH.sub.2CH.sub.2C.sub.6 H.sub.44-F 7.2-6.9 m (4H); 4.7-4.4     m (2H);          3.8-2.6 m (2H); 2.8-2.0 m (2H); 2.0-          1.4 m     (7H); 1.1 d + t (9H) 22 1 H H H CH(CH.sub.3)CH.sub.2 CH.sub.3 C.sub.2     H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.2 s (4H); 4.7-4.4     m (1H); 3.8-2.6 m          (5H); 2.8-2.0 m (2H); 2.2 s (3H);     1.9-1.4 m (5H); 1.1 d + 2 t (9H) 23 1 H C.sub.2      H.sub.5 H CH(CH.sub.3)CH.sub.2 CH.sub.3 C.sub.2      H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.2 s (4H); 4.7-4.4     m (1H); 4.2 q          (2H); 3.8-2.6 m (5H); 2.8-2.0 m (2H);     2.2 s (3H); 1.9-1.4 m (5H); 1.3-0.9 m          (12H)  24 1 H H H     CH.sub.2 CONH.sub.2 C.sub.2      H.sub.5 H     ##STR19##      7.3-6.9 m (3H); 4.7-4.4 m (1H); 3.8-2.6 m (5H); 2.8-2.0 m (4H); 1.9-1.4     m(2H); 1,0 t (3H)  25 1 H C.sub.2 H.sub.5 H CH.sub.2 CONH.sub.2 C.sub.2     H.sub.5 H      ##STR20##      7.3-6.9 m (3H); 4.7-4.4 m (1H); 4.2 q(2H); 3.8-2.6 m (5H); 2.8-2.0 m     (4H);1.9-1.4 m (2H) 1,2 t (3H); 1.0 t (3H)  26 0 H C.sub.2 H.sub.5 H     CH.sub.2 CONH.sub.2 C.sub.2 H.sub.5 -- CH.sub.2 CH.sub.2C.sub.6      H.sub.43-CN 7.6-7.0 m (4H); 4.8-4.3 m (2H); 4.2 q          (1H);     2.8-2.0 m (4H); 1.9-1.4 m (2H);          1.2 t (3H) 27 1 H H H CH.sub.2     CH.sub.2 COOH CH.sub.3 H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2 s (5H);     4.7-4.4 m (1H); 3.6-2.8 m          (3H); 2.8-2.0 m (4H); 2.0 s (3H);          1.8-1.4 m (4H) 28 1 H H H CH.sub.2 CH.sub.2 CONH.sub.2 CH.sub.3 H     CH.sub.2 CH.sub.2C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.4 m (1H); 3.6-2.8 m            (3H); 2.8-2.0 m (4H); 2.0 s (3H)          1.8-1.4 m (4H)  29 1 H     C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 CONH.sub.2 C.sub.2 H.sub.5 H      ##STR21##      8.6-7.2 m (4H); 4.7-4.4 m (1H);4.2 g (2H); 3.6-2.8 m (5H); 2.8-2.0     m(4H); 1.8-1.4 m (4H); 1.2 2 t (6H)  30 1 H H H (CH.sub.2).sub.4     NH.sub.2 C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2C.sub.6 H.sub.5 7.25 (5H);     4.7-4.4 m (1H); 3.6-2.8 m          (5H); 2.8-2.0 m (4H); 1.9-1.3 m (8H);              1.1 t (3H)  31 1 H C.sub.2 H.sub.5 H (CH.sub.2).sub.4 NH.sub.2      ##STR22##      CH.sub.3 CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.4 m (1H);     3.6-2.8 m(4H); 2.8-2.0 m (4H); 4.2 (2H);1.9-1.1 m (14H) 1.2-1.0 2 t + d     (9H)  32 1 H H CH.sub.3 CH.sub.2                                         C      SH CH.sub.2CHCH.sub.2 H CH.sub.2CH.sub.2.sub.6 H.sub.42-CH.sub.3 7.2 s     (4H); .8 m (1H); 5.0-4.3 m          (5H); 3.6-2.7 m (3H); 2.8-2.0 m (4H)              2.1 s (3H); 1.9-1.4 m (2H) 33 1 H H H CH.sub.2 SH CH.sub.2     CH.sub.2 CH.sub.3 H CH.sub.2CH.sub.2C.sub.6 H.sub.44-NHOOCH.sub.3     7.1-6.7 m (4H); 4.8-4.3 m (1H); 3.6-          2.7 m (5H); 2.8-2.0 m     (4H); 2.0 s          (3H); 1.9-1.4 m (4H); 1.1 t (3H) 34 0 H C.sub.2     H.sub.5 H CH.sub.2 SH C.sub.2 H.sub.5 -- CH.sub.2CH.sub.2C.sub.6 H.sub.5     7.2 s (5H); 4.8-4.3 m (2H); 4.2 q          3.8-2.8 m (2H); 2.8-2.0 m     (4H);          1.9-1.4 m (2H); 1.2 t (3H) 35 1 H H H CH.sub.2 SC.sub.6     H.sub.5 C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (10H);     4.8-4.3 m (1H); 3.8-2.8 m          (6H); 3.4-2.8 m (1H); 1.9-1.4 m (2H)             1.1 t (3H) 36 1 H C.sub.2 H.sub.5 H CH.sub.2 SC.sub.5 H.sub.5     C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (10H); 4.8-4.3     m (1H); 4.2 q          (2H); 3.8- 2.8 m (6H); 3,4-2.8 m (1H);     1.9-1.4 m (2H); 1.3-1.0 m (6H) 37 1 H H H CH.sub.2 CH.sub.2 SCH.sub.3     CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.4 m (1H);     3.8-2.8 m          (3H); 2.8-2.0 m (4H); 2.2 s (3H);          2.1 s     (3H); 1.9-1.4 m (4H) 38 1 H C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2      SCH.sub.3 CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2C.sub.6      H.sub.5(OCH.sub.3).sub.23.4 6.8-6.3 m (3H); 4.7-4.4 m (1H); 4.2 q        (2H); 4.0 s (6H); 3.8-2.8 m (4H),          2.8-2.0 m (4H); 2.2 s     (3H); 1.9-1.4 m          (4H); 1.0 d (6H) 39 1 H H CH.sub.3 CH.sub.2     CH.sub.2 SCH.sub.3 CH.sub.2      CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2 s (5H);     4.7-4.4 m (1H); 3.8-2.8 m          (3H); 2.8-2.0 m (4H); 2.2 s (3H)         2.0 s (3H) 1.9-1.4 m (6H); 1.0 d + t          (6H) 40 0 H C.sub.2     H.sub.5 H CH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.2 CH.sub.2 CH.sub.3 --     CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.3 m (2H); 4.2 q       (2H); 3.8-2.8 m (2H); 2.8-2.0 m (4H)          2.2 s (3H); 1.9-1.4 m     (6H); 1.2 t (3H)          1,0 t (3H) 41 1 H H H CH.sub.2 C.sub.6 H.sub.5     CH.sub.3 H (CH.sub.2).sub.3CH.sub.3 7.2 s (5H); 4.7-4.3 m (1H); 3.8-2.6     m          (3H); 2.8-2.0 m (2H); 2.0 s (3H);          1.9-1.3 m (6H);     1.2 t (3H) 42 1 H H H CH.sub.2 C.sub.6 H.sub.5 C.sub.2 H.sub.5 H         S    C     CH.sub.2.sub.6 H.sub.5 7.2-6.9 m (10H); 4.7-4.3 m (1H); 3.8-     2.6 m (6H), 2.8-2.0 m (2H); 1.0 t (3H) 43 1 H H H CH.sub.2 C.sub.6     H.sub.5 C.sub.2 H.sub.5 H CH.sub.2SOC.sub.6 H.sub.5 7.4-6.9 m (10H);     4.7-4.3 m (1H); 3.8-          2.6 m (6H); 2.8-2.0 m (2H); 1.0 t (3H) 44     1 H C.sub.2 H.sub.5 H CH.sub.2 C.sub.6 H.sub.5 CH.sub.2CHCH.sub.2     CH.sub.3 CH.sub.2NHC.sub.6 H.sub.5 7.1-6.4 m (10H); 5.8 m (1H); 4.8-4.3             m (5H); 4.2 q (2H); 3.8-2.6 m (5H);          2.8-2.0 m (2H); 1.3     t (3H)  45 1 H H CH.sub.3 CH.sub.2 C.sub.6      H.sub.5     ##STR23##      H      ##STR24##      8.0 s (1H); 7.8-6.9 m (10H); 4.7-4.3 m(1H); 3.9-2.8 m (4H); 2.8-2.0 m     (4H);2.1 s (3H); 1.9-1.4 m (10H)  46 1 H C.sub.2 H.sub.5 H CH.sub.2     C.sub.6      H.sub.5 CH(CH.sub.3).sub.2 H     ##STR25##      7.3-6.9 m (6H); 4.7-4.4 m (1H); 4.2 q(2H); 3.8-2.6 m (4H); 2.7 s (3H);     2.3s (3H); 2.8-2.0 m (4H); 1.3 t (3H);1.1 d (6H)  47 1 H H H CH.sub.2     C.sub.6 H.sub.5 C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2C.sub.6 H.sub.5 7.2 s     (10H); 4.7-4.4 m (1H); 3.8-2.6 m          (5H); 2.8-2.0 m (4H); 1.9- 1.4     m (2H);          1.1 t (3H) 48 0 H H H CH.sub.2 C.sub.6 H.sub.5 C.sub.2     H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2 s (10H); 4.8-4.3 m (2H);     3.8-2.6 m          (2H); 1.9-1.4 m (2H); 1.2 t (3H) 49 0 H C.sub.2     H.sub.5 H CH.sub.2 C.sub.6 H.sub.5 CH.sub.2 CH.sub.2      CH.sub.3 H CH.sub.2CH.sub.2C.sub.6 H.sub.44-F 7.3-6.9 m (9H); 4.8-4.3 m     (2H); 3.8-          2.6 m (2H); 4.2 q (2H); 1.9-1.4 m          (4H); 1.2     t (3H); 1.0 t (3H) 50 0 H C.sub.2 H.sub.5 H CH.sub.2 C.sub.6 H.sub.5     CH.sub.2CHCHCH.sub.3 H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2 s (10H);     5.5-5.1 m (2H); 4.8-4.1 m          (4H); 4.2 q (2H); 2.8-2.0 m (4H);          2.2 d (3H); 1.9-1.4 m (2H); 1.2 t (3H)      51 1 H H H     ##STR26##      CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.6 d (1H); 6.7 d (1H);     7.2 s (5H);4.7-4.3 m (1H); 3.8-2.6 m (3H); 2.3 s(3H); 2.8-2.0 m (4H);     1.9-1.4 m (2H)   52 1 H C.sub.2 H.sub.5 H " C.sub.2 H.sub.5 H CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 7.6 d (1H); 7.2 s (5H); 6.7 d (1H);     4.7-4.3 m (1H); 4.2 q (2H); 3.8-2.6 m          (5H); 2.8-2.0 m (4H);     1.9-1.4 m (2H);          1.2 t (3H) 53 1 H H H CH.sub.2 OH CH.sub.3 H     CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.3 m (1H); 3.8-2.6 m             (5H); 2.8-2.0 m (2H); 2.2 s (3H); 1.9-          1.4 m (2H); 54 1     H C.sub.2 H.sub.5 H CH.sub.2 OH C.sub.2 H.sub.5 H CH.sub.2      CH.sub.2C.sub.6 H.sub.44-OCH.sub.3 6.9-6.5 m (4H); 4.7-4.3 m (1H); 4.2     q          (3H); 4.0 s (3H); 3.8-2.6 m (7H);          2.8-2.0 m (2H);     1.9-1.4 m (2H); 1.0 t          (3H); 1.1 t (3H) 55 1 H H H CH.sub.2     OCH.sub.3 CH(CH.sub.3).sub.2 H CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H);     4.7-4.3 m (1H); 3.9-2.6 m          + s (9H); 2.8-2.0 m (2H); 1.1 d (6H)     56 1 H H H CH.sub.2 OCH.sub.3 CH(CH.sub.3).sub.2 H CH.sub.3 4.7-4.3 m     (1H); 3.9-2.6 m + s (9H);          1.2 d (9H) 57 1 H H H CH.sub.2     OCH.sub.3 CH(CH.sub.3).sub.2 H H 4.7-4.3 m (1H); 3.9-2.6 m + s (9H);          2.4-2.0 m (2H); 1.2 d (6H)  58 1 H C.sub.2      H.sub.5 H     ##STR27##      CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 8.0 s (1H); 7.8-6.8 m     (10H); 4.7-4.3 m(1H); 4.2 q (2H); 3.8-2.7 m (3H); 2.82.0 m (4H); 1.9-1.3     m (2H); 2.0 s (3H)1.2 t (3H)  59 1 H H H " C.sub.2      H.sub.5 H     ##STR28##      8.0 s (1H); 7.8-6.8 m (10H); 4.7-4.3 m(1H); 3.8-2.7 m (5H); 2.8-2.0 m     (4H);1.9-1.3 m (2H); 1.1 t (3H)  60 1 H H H CH.sub.2 CH.sub.2 OCH.sub.3     CH.sub.3 H CH.sub.2 CH.sub.3 4.7-4.3 m (1H); 3.8-2.7 m +  s (8H);       2.3 s (3H); 1.9-1.4 m (4H); 1.1 t (3H) 61 1 H C.sub.2 H.sub.5 CH.sub.3     CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.2CHCH.sub.2 H CH.sub.2      CH(CH.sub.3).sub.2 5.8 m (1H); 4.9-4.1 m (5H); 3.7-2.9          m + s     (8H); 4.2 q (2H) 1.9-1.4 m (5H);          1.0 d (9H) 62 0 H C.sub.2     H.sub.5 H CH.sub.2 CH.sub.2 OCH.sub.3 C.sub.2 H.sub.5 -- CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 7.2 m (5H); 4.9-4.3 m (2H); 3.7-2.9          m     + s (7H); 4.2 q (2H); 2.8-2.0 m (2H)          1.9-1.4 m (4H); 1.3 t     (3H); 1.0 t (3H) 63 1 H H CH.sub.3 (CH.sub.2).sub.4 NHOOCH.sub.3     CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.4 m (1H);     3.7-2.9 m          (2H); 2.8-2.0 m (4H); 2.1 s (9H);          1.9-1.3 m     (8H); 1.1 d (3H) 64 1 H C.sub.2 H.sub.5 H (CH.sub.2).sub.4 NHOOCH.sub.3     CH(CH.sub.3).sub.2 H (CH.sub.2).sub.4 CH.sub.3 4.7-4.4 m (1H); 4.2 q     (2H); 3.7-2.9 m          (6H); 2.0-1.2 m (14H); 1.3 t (3H);     1.1-0.9 m (9H) 65 1 H H (CH.sub.2).sub.3 CH.sub.3 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2 s (5H); 4.9-4.4 m (1H); 3.8-2.9 m         (5H);     2.8-2.0 m (2H); 2.0 s (3H);         1,9-1.4 m (6H) 66 1 H H (CH.sub.2).su     b.3 C.sub.2 H.sub.5 H CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.9-4.4 m     (1H); 3.8-2.9 m         (7H); 2.8-2.0 m (2H); 1.9-1.4 m (4H)         1.1     t (3H) 67 1 H H (CH.sub.2).sub.3 CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2     CH.sub.2 CH.sub.3 4.8-4.4 m (1H); 3.8-2.9 m (6H);         1.9-1.3 m     (10H); 1.2-0.9 m (9H) 68 1 H H (CH.sub.2).sub.3 CH.sub.2CHCH.sub.2 H     CH.sub.2CH.sub.2CH(CH.sub.3).sub.2 5.8 m (1H); 4.8-4.2 m (5H); 3.8 -2.9     m         (5H); 1.9-1.3 m (9H); 1.0 d (6H) 69 1 H H (CH.sub.2).sub.3     CH.sub.2CCH H CH.sub.2 CH.sub.2C(CH.sub.3).sub.3 4.8-4.2 m (1H); 3.8-2.9     m (7H);         1.9-1.3 m (9H); 0.9 s (9H)  70 1 H H (CH.sub.2).sub.3      ##STR29##      H CH.sub.2 CH.sub.2C.sub.6 H.sub.44-F 7.3-6.8 m (4H); 4.7-4.3 m     (1H);3.8-2.7 m (6H); 2.8-2.0 m (2H);1.9-1.3 m (6H); 1.0-0.6 m (4H)  71 1     H H (CH.sub.2).sub.3 C.sub.2 H.sub.5 H CH.sub.2CH.sub.2C.sub.6      H.sub.32.6-Cl.sub.2 7.3 s (3H); 4.7-4.3 m (1H); 3.7-2.7 m         (7H);     2.8-2.0 m (2H); 1.9-1.3 m (6H)         1.1 t (3H)      72 1 H H (CH.sub.2).sub.3 C.sub.2      H.sub.5 H     ##STR30##      8.0 s (1H); 7.6-6.7 m (5H) 4.7-4.3 m(1H); 3.7-2.7 m (7H); 2.8-2.0 m     (2H);1.1 t (3H)  73 1 H C.sub.2 H.sub.5 (CH.sub.2).sub.3 CH.sub.3 H     CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.3 m (1H); 3.7-2.7 m            (5H); 4.2 q (2H); 2.8-2.0 m (2H); 2.1 s         (3H); 1.9-1.4 m     (6H); 1.3 t (3H) 74 1 H C.sub.2 H.sub.5 (CH.sub.2).sub.3 C.sub.2 H.sub.5     H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.3 m (1H); 4.2 q     (2H)         3.7-2.7 m (7H); 2.8-2.0 m (2H); 1.9-         1.4 m (6H);     1.3 t (3H); 1.0 t (3H) 75 1 H C.sub.2      H.sub.5 (CH.sub.2).sub.3 CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 7.2 s (5H); 4.7-4.3 m (1H); 4.2 q (2H)         3.7-2.7 m (6H);     2.8-2.0 m (2H);         1.9-1.3 m (6H); 1.3 t (3H); 0.9 d (6H) 76 1 H     C.sub.2 H.sub.5 (CH.sub.2).sub.3 CH.sub.2CHCH.sub.2 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2 s (5H); 5.8 m (1H); 4.8-4.1 m (5H)         4.2 q     (2H); 3.7-2.7 m (5H); 2.8-2.0 m         (2H); 1.9-1.4 m (6H); 1.3 t (3H)      77 1 H C.sub.2      H.sub.5 (CH.sub.2).sub.3     ##STR31##      H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.6-4.2 m (1H); 4.2 q     (2H)3.8-2.7 m (6H); 2.8-2.0 m (2H); 1.9-1.4 m (12H); 1.3 t (3H)  78 1 H     C.sub.2 H.sub.5 (CH.sub.2).sub.3 CH.sub.2CCH H CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 7.2 s (5H); 4.7-4.3 m (1H); 4.2 q (2H)         3.8-2.7 m (7H);     2.8-2.0 m (2H);         1.9-1.4 m (7H); 1.3 t (3H) 79 0 H H (CH.sub.2).su     b.3 CH.sub.3 -- CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.9-4.3 m     (2H); 3.8-2.7 m         (2H); 2.3 s (3H); 2.8-2.0 m (2H);     1.9-1.4 m (6H) 80 0 H C.sub.2 H.sub.5 (CH.sub.2).sub.3 C.sub.2 H.sub.5     -- CH.sub.2 CH.sub.2C.sub.6 H.sub.44-F 7.2-6.8 m (4H); 4.9-4.3 m (2H);     4.2 q         (2H); 3.8-2.7 m (4H); 2.8-2.0 m (2H);         1.9-1.4 m     (6H); 1.3 t (3H); 1.1 t         (3H) 81 0 H C.sub.2      H.sub.5 (CH.sub.2).sub.3 C.sub.2 H.sub.5 -- CH.sub.2CH.sub.2CH.sub.3     4.9-4.3 m (2H); 4.2 q (2H); 3.8-2.7 m         (4H); 1.9-1.4 m (8H); 1.1     t (6H) 82 0 H H (CH.sub.2).sub.3 (CH(CH.sub.3).sub.2 -- CH.sub.2         C     CH.sub.2.sub.6 H.sub.44-OCH.sub.3 6.9-6.3 m (4H); 4.9-4.3 m (2H);      3.8-2.7 m (3H); 3.9 s (3H); 2.8-2.0 m         (2H); 1.9-1.4 m (6H); 1.0     d (6H) 83 0 H H (CH.sub.2).sub.3 CH.sub.2CHCH.sub.2 -- CH.sub.2CH.sub.2C.     sub.6 H.sub.3(OCH.sub.3).sub.23.4 6.8-6.0 m (3H); 5.8 m (1H); 4.9-4.3 m            (6H); 4.0 s (6H); 3.8-3.1 m (2H);         2.8-2.0 m (2H); 1.9-1.4     m (6H) 84 0 H H (CH.sub.2).sub.3 CH.sub.2CCCH.sub.3 -- CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2 s (5H); 4.9-4.3 m (2H); 3.8-2.7 m         (4H);     2.8-2.0 m (2H); 1.8 s (3H);         1.8-1.3 m (6H) 85 1 H H CH.sub.2CH(OC     H.sub.3)CH.sub.2 C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2     s (5H); 4.8-4.3 m (1H); 4.1-2.9 m         (8H); 3.2 s (3H); 2.8-2.0 m     (2H);         2.0-1.3 m (6H); 1.0 t (3H) 86 1 H C.sub.2      H.sub.5 CH.sub.2CH(OCH.sub.3)CH.sub.2 CH.sub.3 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.3 m (1H); 4.1-2.9 m         (6H); 4.2     q (2H); 3.2 s (3H); 2.4 s         (3H); 2.8-2.0 m (2H); 2.0-1.4 m (6H);            1.3 t (3H) 87 1 H H CH.sub.2CHCH C.sub.2 H.sub.5 CH.sub.3     CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 6.4-5.5 m (3H); 4.3-2.9 m            (6H); 2.8-2.0 m (2H); 1.9-1.4 m (2H);         1.2 d + t (6H) 88 1     H C.sub.2 H.sub.5 CH.sub.2CHCH CH(CH.sub.3 ).sub.2 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2 s (5H); 6.4-5.5 m (3H); 4.3-2.9 m         (8H);     2.8-2.0 m (2H); 1.6-1.2 m (2H);         1.3 t (3H); 1.0 d (6H) 89 1 H H     CH(CH.sub.3)CH.sub.2CH.sub.2 CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 7.2 s (5H); 4.7-4.3 m (1H), 3.7-2.8 m         (5H); 2.8-2.0 m     (2H); 1.6-1.3 m (5H);         2.1 s (3H); 1.0 d (3H) 90 1 H H CH.sub.2CH(     CH.sub.3)CH.sub.2 C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5     7.2 s (5H); 4.7-4.3 m (1H); 3.7-2.8 m         (7H); 2.8-2.0 m (2H);     1.7-1.3 m (5H); 1.0 d + t (6H) 91 1 H C.sub.2 H.sub.5 CH.sub.2CH(C.sub.6     H.sub.5)CH.sub.2 C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2     s (10H); 4.7-4.3 m (1H); 4.2 q         (2H); 3.7-2.8 m (8H); 2.8-2.0 m     (2H),         1.8-1.4 m (6H); 1.3 t (3H); 1.0 t (3H) 92 1 H H CHC.sub.6     H.sub.5CH.sub.2CH.sub.2 C.sub.3 H.sub.7 H CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 7.2 s (10H); 4.7-4.3 m (1H); 3.7-2.8 m         (8H); 2.8-2.0 m     (2H); 1.8-1.4 m (8H);         1.0 t (3H)  93 1 H H (CH.sub.2).sub.4     CH.sub.3 H      ##STR32##      7.3-6.9 m (3H); 4.7-4.4 m (1H); 3.6-2.8 m (5H); 2.2 s (3H); 2.8-2.0 m     (2H)1.9-1.4 m (8H)  94 1 H C.sub.2 H.sub.5 (CH.sub.2).sub.4 CH.sub.3 H     CH.sub.3 4.7-4.4 m (1H); 4.2 q (2H); 3.6-2.8 m         (5H); 2.2 s (3H);     1.9-1.4 m (6H); 1.1         d (3H) 95 1 H C.sub.2      H.sub.5 (CH.sub.2).sub.4 C.sub.2 H.sub.5 CH.sub.3 CH.sub.2CH.sub.3     4.7-4.4 m (1H); 4.2 q (2H); 3.6-2.8 m         (6H); 1.9-1.4 m (8H); 1.3     t (3H);         1.0 m (9H) 96 1 H H (CH.sub.2).sub.4 CH(CH.sub.3).sub.2     H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.4 m (1H); 3.6-2.8 m            (6H); 2.8-2.0 m (2H); 1.9-1.4 m (8H);         1.0 d (6H)  97 1 H     H (CH.sub.2).sub.4 C.sub.2      H.sub.5 H     ##STR33##      7.4-6.8 m (5H); 4.7-4.4 m (1H); 3.6-2.8 m (7H); 2.8-2.0 m (2H); 1.9-1.4     m (6H); 1.0 t (3H)  98 1 H H (CH.sub.2).sub.4 C.sub.2      H.sub.5 H     ##STR34##      7.6 d (1H); 6.7 d(1H); 4.7-4.4 m (1H)3.6-2.8 m (7H); 2.8-2.0 m (2H);     1.9-1.4 m (8H); 1.0 t (3H)  99 1 H C.sub.2 H.sub.5 (CH.sub.2).sub.4     CH.sub.2CHCH.sub.2 H CH.sub.2CH.sub.2C.sub.6 H.sub.32.6-Cl.sub. 2 7.3 s     (3H); 5.8 m (1H); 4.9-4.3 m         (5H); 4.2 q (2H); 3.6-2.8 m (5H);          2.8-2.0 m (2H); 1.9-1.5 m (8H) 100 1 H H (CH.sub.2).sub.4 CH.sub.2 CC     H H CH.sub.2CH.sub.2C.sub.6 H.sub.3Cl 2-OCH.sub.34 7.3-6.6 m (3H);     4.7-4.3 m (1H); 3.8-         2.8 m (7H); 4.0 s (3H); 2.8-2.0 m (2H)        1.9-1.5 m (9H)  101 1 H C.sub.2      H.sub.5 (CH.sub.2).sub.4 CH.sub.2CH.sub.3 CH.sub.3      ##STR35##      7.4 s (1H); 4.7-4.3 m (1H); 4.2 q (2H)3.8-2.8 m (6H); 2.3 s (3H); 2.1 s     (3H)2.8-2.0 m (2H); 1.9-1.4 m (8H); 1.3 t(3H); 1.0 d (3H)  102 1 H H     (CH.sub.2).sub.4 CH.sub.3 H CH.sub.2C.sub.6 H.sub.5C.sub.6 H.sub.5     7.4-6.8 m (9H); 4.7-4.3 m (1H); 3.8-         2.8 m (5H); 2.2 s (3H);     2.8-2.0 m (2H)         1.9-1.4 m (6H)  103 1 H C.sub.2      H.sub.5 (CH.sub.2).sub.4      ##STR36##      H CH.sub.3 4.7-4.3 m (1H); 4.2 q (2H); 3.8-2.8 m(6H); 1.9-1.3 m (14H);     1.3 t (3H); 1.0 d(3H)  104 1 H H (CH.sub.2).sub.4 C.sub.2 H.sub.5 H      ##STR37##      7.5 s (1H); 7.1 s (5H); 4.7-4.3 m (1H)3.8-2.8 m (7H); 2.8-2.0 m (2H);     1.9-1.4 m (8H); 1.0 t (3H)  105 1 H H (CH.sub.2).sub.4 C.sub.2 H.sub.5 H     CH.sub.2 CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.3 m (1H);     3.8-2.9 m         (7H); 2.8-2.0 m (2H); 1.9-1.4 m         (10H); 1.0 t     (3H) 106 0 H H (CH.sub.2).sub.4 CH.sub.3 -- CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 7.2 s (5H); 4.9-4.2 m (2H); 3.8-2.9 m         (2H); 2.8-2.0 m     (2H); 2.2 s (3H);         1.9-1.5 m (8H) 107 0 H H (CH.sub.2).sub.4     C.sub.2 H.sub.5 -- CH.sub.2CH.sub.2C.sub.6 H.sub.44-F 7.2-6.8 m (4H);     4.9-4.2 m (2H);3.8-         2.9 m (4H); 2.8-2.0 m (2H); 2.0-1.5 m      (8H); 1.0 t (3H) 108 0 H C.sub.2      H.sub.5 (CH.sub.2).sub.4 CH(CH.sub.3).sub.2 -- CH.sub.2CH.sub.2C.sub.6     H.sub.3(OCH.sub.3).sub.23.4 6.9-6.2 m (3H); 4.9-4.2 m (2H); 4.2 q      (2H); 4.0 s (6H); 3.8-2.9 m (3H);         2.8-2.0 m (2H); 1.9-1.4 m     (8H); 1.0 d         (6H); 1.3 t (3H) 109 0 H C.sub.2      H.sub.5 (CH.sub.2).sub.4 CH.sub.2CHCH.sub.2 -- CH.sub.2CH.sub.2C.sub.6     H.sub.5 7.2 s (5H); 4.9-4.2 m (6H); 4.2 q (2H)         5.8 m (1H);     2.8-2.1 m (2H); 1.9-1.4 m         (8H); 1.3 t (3H) 110 1 H H (CH.sub.2).s     ub.5 CH.sub.3 H CH.sub.2 CH.sub. 2 C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.3 m     (1H); 3.8-2.8 m         (5H); 2.8-2.0 m (2H); 2.3 s (3H);     1.9-1.4 m (10H) 111 1 H C.sub.2 H.sub.5 (CH.sub.2).sub.5 C.sub.2 H.sub.5     H CH.sub.2CH.sub.2C.sub.6 H.sub.4 2-CH.sub.3 7.2 s (4H); 4.7-4.3 m (1H);     4.2 q (2H)         3.8-2.8 m (7H); 2.2 s (3H); 2.8-2.0 m         (2H);     1.9-1.4 m (10H); 1.3 t (3H) 1.1         t (3H) 112 1 H H (CH.sub.2).sub.5      CH(CH.sub.3).sub.2 H CH.sub.2CH.sub.2C.sub.6 H.sub.32-Cl 4-OCH.sub.3     7.1-6.5 m (3H); 4.7-4.3 m (1H);         3.8-2.8 m (6H); 4.0 s (3H);     2.8-2.0 m         (2H); 1.9-1.4 m (10H); 1.1 d (6H);  113 1 H C.sub.2     H.sub. 5 (CH.sub.2).sub.5      ##STR38##      H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.3 m (1H); 3.8-2.8     m(6H); 4.2 q (2H); 2.8-2.0 m (2H);1.9-1.4 m (16H); 1.3 t (3H)  114 1 H H     (CH.sub.2).sub.5      ##STR39##      H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.4 m (1H); 3.8-2.8     m(6H); 2.8-2.0 m (2H); 1.9-1.4 m (18H)  115 1 H H (CH.sub.2).sub.5     CH.sub.2CHCHCH.sub.3 H      ##STR40##      8.6-7.2 m (4H); 5.8-5.4 m (2H); 4.9-4.2 m (5H); 3.8-2.9 m (5H); 2.8-2.1     m(2H); 1.9-1.4 m + s (13H)  116 1 H C.sub.2 H.sub.5 (CH.sub.2).sub.5     CH.sub.2CH(CH.sub.3).sub.2 H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2 s (5H);     4.7-4.4 m (1H); 4.2 q (2H)         3.8- 3.1 m (7H); 2.9-2.4 m (2H);        1.9-1.4 m (11H); 1.1 d (6H) 117 1 H H (CH.sub.2).sub.5 CH.sub.3     CH.sub.3 n-C.sub.4 H.sub.9 4.7-4.4 m (1H); 3.8-3.1 m (4H); 2.2 s     (3H); 1.9-1.4 m (14H); 1.0 d + t (3H) 118 1 H H (CH.sub.2).sub.5 C.sub.2     H.sub.5 H CH.sub.2CH.sub.2CH(CH.sub.3).sub.2 4.7-4.4 m (1H); 3.8-3.1 m     (7H); 1.9-         1.4 m (13H); 1.0 d + t (9H) 119 1 H C.sub.2 H.sub.5     (CH.sub.2).sub.5 CH(CH.sub.3).sub.2 H CH.sub.2SO.sub.2C.sub.6 H.sub.5     7.4-6.8 m (5H); 4.7-4.4 m (1H); 4.2 q         (2H); 3.8-3.0 m (8H);     1.9-1.4 m (8H);         1.3 t (3H); 1.1 d (6H)      120 1 H H     ##STR41##      CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.44-F 7.3-6.9 m (8H); 4.7-4.2     m (3H); 3.5-2.9 m (3H); 2.8-2.3 m (4H); 1.9-1.4 m(2H); 2.2 s (3H)  121 1     H C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.44-F     7.3-6.9 m (8H); 4.7-4.3 m (3H); 4.2 q         (2H); 3.5-2.9 m (3H);     2.8-2.3 m (4H)         1.9-1.4 m (2H); 2.2 s (3H); 1.2 t (3H) 122 1 H H     " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2C.sub.6 H.sub.4 4-OCH.sub.3 7.2-6.5     m (8H); 4.7-4.3 m (3H); 3.8-         2.9 m (5H); 4.0 s (3H); 2.8-2.3 m     (4H)         1.9-1.4 m (2H); 1.1 t (3H) 123 1 H C.sub.2 H.sub.5 "     C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2C.sub.6 H.sub.44-OCH.sub.3 7.2-6.5 m     (8H); 4.7-4.3 m (3H); 4.2 q         (2H); 3.8-2.9 m (5H); 4.0 s (3H);          2.8-2.3 m (4H); 1.9-1.4 m (2H); 1.3 t         (3H); 1.1 t (3H) 124     1 H H " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2C.sub.6 H.sub.42-CH.sub. 3     7.2-6.8 m (8H); 4.7-4.3 m (3H); 4.0-         2.9 m (4H); 2.8-2.3 m (4H);     2.3 s         (3H); 1.9-1.4 m (2H); 1.0 d (6H) 125 1 H C.sub.2 H.sub.5 "     CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2C.sub.6 H.sub.42-CH.sub. 3 7.2-6.8     m (8H); 4.7-4.3 m (3H); 4.2 q         (2H); 4.0-2.9 m (4H); 2.8-2.3 m     (4H);         2.3 s (3H);1.9-1.4 m (2H); 1.3 t (3H)         1.0 d (6H)     126 1 H H " CH.sub.2CHCH.sub.2 H CH.sub.2 CH.sub.2CH(CH.sub.3).sub.2 7.2     s (4H); 5.8 m (1H); 5.0-4.3 m         (7H); 3.5-2.9 m (3H); 2.8-2.3 m     (2H);         1.9-1.4 m (5H); 1.0 d (6H) 127 1 H H " CH.sub.3 H CH.sub.3     7.2 s (4H); 4.7-4.3 m (3H); 3.5-2.9 m         (3H); 2.8-2.3 m (2H); 2.3     s (3H); 1.1         d (6H)      128 1 H H "     ##STR42##      H CH.sub.2SC.sub.6 H.sub.5 7.3-6.9 m (9H); 4.7-4.3 m (3H); 3.5-2.9 m     (6H); 1.1-0.6 m (4H) 129 1 H H " C.sub.2      H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.44-N(CH.sub.3).sub.2 7.2-6.4 m     (8H); 4.7-4.3 m (3H); 3.5-         2.9 m (5H); 2.9 s (6H); 2.8-2.3 m         (4H); 1.9-1.4 m (2H); 1.1 t (3H) 130 1 H C.sub.2 H.sub.5 " n-C.sub.4     H.sub.9 CH.sub.3 CH.sub.2CH.sub.2C.sub.6 H.sub.33-CN 7.6-7.0 m (8H);     4.7-4.3 m (3H); 4.2 q         (2H); 3.8-2.9 m (5H); 2.8-2.3 m (4H);        1.9-1.4 m (6H); 1.3 t (3H); 1.0 t (3H)      131 1 H H " CH.sub.2CH.sub.2CH.sub.3 H      ##STR43##      8.6-7.2 m (8H); 4.7-4.3 m (3H); 3.8-2.9 m (5H); 2.8-2.3 m (4H); 1.9-1.4     m(4H); 1.0 t (3H)      132 1 H H " CH.sub.3 H     ##STR44##      7.3-6.8 m (8H); 4.7-4.3 m (3H); 3.52.9 m (3H); 2.3 s (3H); 2.8-2.3 m     (4H)1.9-1.4 m (2H)      133 1 H H "     ##STR45##      H      ##STR46##      8.0 s (1H); 7.2 s (4H), 4.7-4.3 m (3H)4.0-2.9 m (4H), 2.9-2.3 m (4H);     3.9 s(3H); 1.9-1.2 m (8H)  134 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H     CH.sub.2CH.sub.2C.sub.6 H.sub.3(OCH.sub.2 O)3.4 7.2-6.2 m (7H); 5.0 s     (2H); 4.7-4.3 m         (3H); 4.2 q (2H); 3.9-2.9 m (5H);     2.9-2.3 m (4H); 1.9-1.4 m (2H); 1.3 t         (3H) 135 1 H H " CH.sub.3     CH.sub.3 CH.sub.2CH.sub.2C.sub.6 H.sub.4OC.sub.6 H.sub.54 7.2-6.7 m     (13H); 4.7-4.3 m (3H);         4.0-2.9 m (2H); 2.9-2.3 m (2H); 2.4 s         (3H); 1.9-1.4 m (2H); 1.1 d (3H) 136 0 H H " CH.sub.3 -- CH.sub.2CH.s     ub. 2C.sub.6 H.sub.5 7.2 s (9H); 4.7-4.3 m (4H); 2.9-2.3 m         (4H);     2.3 s (3H); 1.9-1.4 m (2H) 137 0 H C.sub.2 H.sub.5 " CH.sub.3 --         C     CH.sub.2H.sub.2C.sub.6 H.sub.5 7.2 s (9H); 4.7-4.3 m (4H); 4.2 q (2H)          2.9-2.3 m (4H); 2.3 s (3H) 1.9-1.4 m         (2H); 1.3 t (3H) 138 0     H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 -- CH.sub.2CH.sub.2C.sub.6      H.sub.44-F 7.3-6.9 m (8H); 4.7-4.3 m (4H); 4.2 q         (2H); 3.6-2.9     m (2H); 2.9-2.3 m (4H);         1.9-1.4 m (2H); 1.3 t (3H); 1.0 t (3H)     139 0 H H " CH(CH.sub.3).sub.2 --      ##STR47##      7.3-6.8 m (7H); 4.7-4.3 m (4H); 4.03.5 m (1H); 2.9-2.3 m (4H); 1.9-1.4m(     2H); 1.1 d (6H)  140 0 H C.sub.2 H.sub.5 " CH(CH.sub.3).sub.2 --         C     CH.sub.2H.sub.2C.sub.6 H.sub.3(OCH.sub.3).sub.23.4 7.3-6.2 m (7H);     4.7-4.3 m (4H); 4.2 q         (2H); 4.0-3.5 m (1H); 4.0 s (6H);     2.9-2.3 m (4H); 1.9-1.4 m (2H); 1.3 t         (3H); 1.1 d (6H) 141 0 H H     " CH.sub.2CHCH.sub.2 -- CH.sub.2CH.sub.2C.sub.6 H.sub.42-CH.sub. 3 7.2 s     (8H); 5.8 m (1H); 5.0-4.2 m (6H)         2.9-2.3 m (4H); 2.2 s (3H);     1.9-1.4 m         (2H)  142 0 H C.sub.2      H.sub.5 "     ##STR48##      -- CH.sub.2 CH.sub.2C.sub.6 H.sub.52-Cl 4-OCH.sub.3 7.2-6.6 m (7H);     4.6-4.3 m (4H); 4.2 q (2H); 4.0-3.5 m (1H); 4.0 s (3H);2.9-2.3 m (4H);     1.9-1.3 m (10H); 1.3 t(3H)  143 0 H H " C.sub.4 H.sub.9 -- CH.sub.2     CH.sub.2C.sub.6 H.sub.3 2.6-Cl.sub.2 7.4-6.8 m (7H); 4.7-4.3 m (4H);         3.8-3.1 m (2H); 2.9-2.3 m (4H);         1.9-1.4 m (8H); 1.0 t (3H)     144 1 H H      ##STR49##      CH.sub.3 H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2-6.5 m (8H); 4.7-4.3 m     (3H),4.0 s (3H); 3.5-2.9 m (3H); 2.8-2.3 m (4H); 1.9-1.4 m (2H); 2.2     s(3H)  145 1 H C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.2CH.sub.2C.sub.6     H.sub.5 7.2-6.5 m (8H); 4.7-4.3 m (3H); 4.2         q (2H); 4.0 s (3H);     3.6-2.9 m (5H);         2.8-2.3 m (4H); 2.2 s (3H); 1.9-1.4         m     (2H); 1.2 t (3H) 146 1 H H " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2C.sub.6     H.sub.44-F 7.3-6.5 m (7H); 4.7-4.3 m (3H); 4.0         s (3H); 3.6-2.9 m     (5H); 2.8-2.3 m         (4H); 1.9-1.4 m (2H); 1.0 t (3H) 147 1 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2CH.sub.2C.sub.6 H.sub.42-CH.sub.     3 7.3-6.5 m (7H); 4.7-4.3 m (3H); 4.2 q         (2H); 4.0 s (3H);     4.0-2.9 m (4H);         2.8-2.3 m (4H); 2.2 s (3H); 1.3 t         (3H);     1.0 d (6H) 148 1 H H " CH.sub.2CCH H CH.sub.2CH.sub.2C.sub.6      H.sub.4 4-CH.sub.3 7.3-6.5 m (7H); 4.7- 4.0 m (5H);         3.5-2.9 m     (3H); 4.0 s (3H); 2.8-2.3         m (4H); 2.2 s (3H); 1.9-1.4 m (3H)     149 1 H H "      ##STR50##      CH.sub.3 CH.sub.2CH.sub.2CH(CH.sub.3).sub.2 6.8-6.4 m (3H); 4.7-4.3 m     (3H); 3.8-2.9 m (4H); 4.0 s (3H); 2.8-2.3 m(2H); 1.9-1.4 m (6H); 1.0 d     (15H)      150 1 H H "     ##STR51##      H CH.sub.2CH.sub.2C.sub.6 H.sub.4 4-Cl 7.3-6.5 m (7H); 4.7-4.3 m     (3H);3.8-2.9 m (4H); 4.0 s (3H); 2.8-2.3 m(4H); 1.9-1.4 m (2H); 1.1-0.6     m (4H)  151 1 H H " C.sub.2      H.sub.5 H     ##STR52##      8.0 s (1H); 7.6-6.5 m (8H); 4.7-4.3 m(3H); 3.8-2.9 m (5H); 4.0 s (3H);  2      .8-2.3 m (4H); 1.2 t (3H)  152 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H      ##STR53##      7.3-6.5 m (8H); 4.7-4.3 m (3H); 4.2 q,(2H); 4.0 s (3H); 3.8-2.9 m (5H); 2     .8-2.3 m (4H); 2.2 s (3H); 1.9-1.4 m(2H); 1.3 t (3H); 1.1 t (3H)  153 1     H H " CH(CH.sub.3).sub.2 H      ##STR54##      7.3-6.5 m (8H); 4.7-4.3 m (3H); 4.0 s(3H); 4.0-2.9 m (4H); 2.8-2.3 m     (4H);1.1 d (6H)  154 1 H C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.2 CH.sub.2     SC.sub.6 H.sub.5 7.3-6.5 m (8H); 4.7-4.3 m (3H); 4.2 q         (2H); 4.0     s (3H); 3.7-2.7 m (5H);         2.7-2.3 m (2H); 2.3 s (3H); 1.9-1.4        m (2H); 1.3 t (2H) 155 1 H H " CH.sub.3 H CH.sub.2NHOOC.sub.6 H.sub.5     7.8-6.5 m (8H); 4.7-1.3 m (3H); 4.0 s         (3H); 3.5-2.8 m (5H);     2.7-2.3 m (2H);         2.4 s (3H)      156 1 H H     ##STR55##      CH.sub.3 H CH.sub.2 CH.sub.2C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.3 m(1H);     3.5-2.9 m(5H); 2.8-2.4 m (2H); 2.3 s (3H);1.9-1.3 m (14H)  157 1 H     C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.2 CH.sub.2C.sub.6 H.sub.5 7.2 s     (5H); 4.7-4.3 m (1H); 4.2 q         (2H); 3.5-2.9 m (5H); 2.8-2.4 m     (2H);         2.3 s (3H); 1.9-1.3 m (14H); 1.2 t         (3H) 158 1 H H     " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2C.sub.6 H.sub.44-F 7.3-6.9 m (4H);     4.7-4.3 m (1H); 3.8-         2.9 m (7H); 2.8-2.4 m (2H); 1.9-1.3     m (14H); 1.1 t (3H) 159 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2     CH.sub.2C.sub.6 H.sub.44-F 7.3-6.9 m (4H); 4.7-4.3 m (1H); 4.2 q     (2H); 3.8-2.9 m (7H) 2.8-2.4 m (2H)         1.9-1.3 m (14H); 1.3 t (3H);     1.1 t (3H) 160 1 H H " C.sub.2 H.sub.5 H CH.sub.2CH.sub.2C.sub.6     H.sub.44-OCH.sub. 3 6.9-6.4 m (4H); 4.7-4.3 m (1H); 3.8-         2.9 m     (7H);4.0 s (3H); 2.8-2.4 m (2H);         1.9-1.3 m (14H); 1.1 t (3H) 161     1 H C.sub. 2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2CH.sub.2C.sub.6     H.sub.44-OCH.sub. 3 6.9-6.4 m (4H); 4.7-4.3 m (1H); 4.2 q         (2H);     4.0 s (3H); 3.8-2.9 m (7H);         2.8-2.4 m (2H); 1.9-1.3 m (14H); 1.3     t         (3H); 1.1 t (3H) 162 1 H H " CH(CH.sub.3).sub.2 H CH.sub.2CH.su     b.2C.sub.6 H.sub.42-CH.sub. 3 7.2 s (4H); 4.7-4.3 m (1H); 3.9-2.9 m        (6H); 2.8-2.4 m (2H); 2.2 s (3H);         1.9-1.3 m (14H); 1.0 d (6H)     163 1 H C.sub.2 H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2CH.sub.2C.sub.6     H.sub.4 2-CH.sub.3 7.2 s (4H); 4.7-4.3 m (1H); 4.2 q         (2H);     3.9-2.9 m (6H); 2.8-2.4 m (2H);         2.2 s (3H); 1.9-1.3 m (14H); 1.2     t         (3H); 1.0 d (6H)      164 1 H H " CH.sub.2CHCH.sub.2 H     ##STR56##      5.8 m (1H); 5.0-4.2 m (5H); 3.9-2.8 m(5H); 1.9-1.2 m (27H)  165 1 H H "     CH.sub.3 H C.sub.2 H.sub.5 4.7-4.3 m (1H); 3.5-2.9 m (5H); 2.4 s     (3H); 1.9-1.3 m (14H); 0.9 t (3H)      166 1 H H "     ##STR57##      H CH.sub.2 SOC.sub.6 H.sub.5 7.2-6.8 m (5H); 4.7-4.3 m (1H);3.8-2.9 m     (8H); 1.9-1.3 m (18H)  167 1 H H " C.sub.2 H.sub.5 CH.sub.3 CH.sub.2     NHOOC.sub.6 H.sub.5 7.7-7.1 m (5H); 4.7-4.3 m (1H);         3.8-2.9 m     (8H); 1.9-1.3 m (12H);         1.0 d + t (6H) 168 1 H C.sub. 2 H.sub.5 "     n-C.sub.3 H.sub.7 H CH.sub.2CH.sub.2C.sub.6      H.sub.32-NO.sub.24-NHCOCH.sub.3 8.1-7.4 m (3H); 4.7-4.3 m (1H); 4.2 q           (2H); 3.8-2.9 m (7H); 2.9-2.4 m (2H);         1.9-1.3 m (16H); 2.3     s (3H); 1.3 t         (3H); 0.9 t (3H)  169 1 H H " CH.sub.3 CH.sub.3      ##STR58##      7.5-6.7 m (2H); 4.7-4.3 m (1H);3.9-2.9 m (4H); 3.7 s (3H); 2.8-2.4     m(2H); 1.9-1.4 m (14H); 2.3 s (3H);1.0 d (3H)  170 1 H C.sub.2 H.sub.5 "     C.sub.2 H.sub.5 H CH.sub.2 C.sub.6 H.sub.4C.sub.6 H.sub.5 7.4-7.0 m     (9H); 4.7-4.3 m (1H); 4.2 q         (2H); 3.8-2.9 m (7H); 2.8-2.4 m     (2H);         1.9-1.4 m (12H); 1.3 t (3H); 1.0 t (3H) 171 1 H H "     CH.sub.3 CH.sub.3 CH.sub.2CH.sub.2C.sub.6 H.sub.3(OCH.sub.3).sub.22.5     6.9-6.2 m (3H); 4.7-4.3 m (1H); 4.0 s         (6H); 3.8-2.9 m (4H);     2.8-2.4 m (2H);         1.9-1.4 m (14H); 2.3 s (3H); 1.0 d         (3H)     172 1 H H " C.sub.2      H.sub.5 H     ##STR59##      8.0 s (1H); 7.6-6.8 m (5H); 4.7-4.3 m(1H); 3.8-2.9 m (7H); 2.8-2.4 m     (2H);1.9-1.4 m (12H); 1.1 t (3H)      173 1 H H "     ##STR60##      H CH.sub.2SO.sub.2C.sub.6      H.sub.5 7.6-7.0 m (5H); 4.7-4.3 m (1H);3.8-2.7 m (8H); 1.9-1.4 m (12H); 1     .0-0.6 m (4H)  174 0 H H " CH.sub. 3 -- CH.sub.2 CH.sub.2 C.sub.6     H.sub.6 7.2 s (5H); 4.7-4.3 m (2H); 3.8-2.9 m         (2H); 2.8-2.4 m     (2H); 1.9-1.4 m (14H);         2.4 s (3H) 175 0 H C.sub.2 H.sub.5 "     CH.sub.3 -- CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.3 m     (2H); 4.2 q (2H)         3.8-2.9 m (2H); 2.8-2.4 m (2H); 1.9-     1.4 m (14H); 2.4 s (3H); 1.3 t (3H); 176 0 H H " C.sub.2 H.sub.5 --     CH.sub.2 CH.sub.2 C.sub.6 H.sub.44-F 7.4-6.9 m (4H); 4.7-4.3 m (2H);     3.8-        2.9 m (4H); 2.8-2.4 m (2H); 1.9-1.4 m         (14H); 1.0 t     (3H)  177 0 H C.sub.2      H.sub.5 " CH(CH.sub.3).sub.2 --     ##STR61##      7.4-6.8 m (3H); 4.7-4.3 m (2H);3.9-3.0 m (3H); 4.2 q (2H); 2.8-2.4     m(2H); 1.9-1.4 m (14H); 1.3 t (3H);1.0 d (6H)      178 0 H H " CH.sub.2CHCH.sub.2 -- CH.sub.2 CH.sub.2C.sub.6 H.sub.3     (OCH.sub.3).sub.23.4 6.9-6.2 m (3H); 5.8 m (1H); 4.9-4.1 m         (6H);     3.7-3.0 m (2H); 4.0 s (6H);         2.8-2.4 m (2H); 1.9-1.4 m (14H)  179     0 H C.sub.2      H.sub.5 "     ##STR62##      -- CH.sub.2CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.2 s (4H); 4.7-4.3 m     (1H); 4.2 q (2H)3.8-2.9 m (3H); 2.8-2.4 m (2H); 2.2 s(3H); 1.9-1.4 m     (22H); 1.3 t (3H)  180 0 H H " n-C.sub.3      H.sub.7 -- CH.sub.2CH.sub.2C.sub.6 H.sub.32.6-Cl.sub.2 7.4-6.9 m (3H);     4.7-4.3 m (1H); 3.8-2.9         m (4H); 2.8-2.4 m (2H); 1.9-1.4 m      (16H); 1.0 t (3H)       181 1 H H     ##STR63##      CH.sub.3 H CH.sub.2CH.sub.2 C.sub.6 H.sub.5 7.2-6.5 m (9H); 4.9 t (1H);     3.8-3.0 m(3H); 2.9-2.4 m (4H); 2.4 s (3H);1.9-1.4 m (2H)  182 1 H     C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2-6.5 m     (9H); 4.9 t (1H); 4.2 q (2H)         3.8-3.0 m (3H); 2.9-2.4 m (4H); 2.4     s         (3H); 1.9-1.4 m (2H); 1.2 t (3H) 183 1 H H " C.sub.2 H.sub.5 H     CH.sub.2CH.sub.2C.sub.6 H.sub.44-F 7.2-6.5 m (8H); 4.9 t (1H); 3.8-3.0 m             (5H); 2.9-2.4 m (4H); 1.9-1.4 m (2H);         1.2 t (3H) 184 1 H     C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.44-F     7.2-6.5 m (8H); 4.9 t (1H); 3.8-3.0 m         (5H); 4.2 q (2H); 2.9-2.4     m (4H);         1.9-m (2H); 1.2 t (3H); 1.0 t (3H) 185 1 H H " C.sub.2     H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2-6.5 m (9H); 4.9 t (1H);     3.8-3.0 m(5H); 2.9-2.4 m (4H); 1.9-m (2H);       1.1 t (3H) 186 1 H     C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2CH.sub.2 C.sub.6 H.sub.5     7.2-6.5 m (9H); 4.9 t (1H); 3.8-3.0 m         (5H); 4.2 q (2H); 2.9-2.4     m (4H);         1.9-1.4 m (2H); 1.3 t (3H); 1.1 t (3H) 187 1 H H "     C.sub.2 H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.4OCH.sub.34 7.2-6.4 m     (8H); 4.9 t (1H); 4.0 s (3H)         3.8-3.0 m (5H); 2.9-2.4 m (4H);     1.9-         1.4 m (2H); 1.1 t (3H) 188 1 H C.sub.2 H.sub.5 " C.sub.2     H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.4OCH.sub.34 7.2-6.4 m (8H); 4.9     t (1H); 4.2 q (2H)         4.0 s (3H); 3.8-3.0 m (5H); 2.9-2.4 m     (4H); 1.9-1.4 m (2H); 1.3 t (3H); 1.1         t (3H) 189 1 H H "     CH(CH.sub.3).sub.2 H CH.sub.2CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.2-6.5 m     (8H); 4.9 t (1H); 3.8-3.0 m         (4H); 2.9-2.4 m (4H); 2.2 s (3H);          1.9-1.4 m (2H); 1.0 d (6H) 190 1 H C.sub.2      H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2CH.sub.2C.sub.6      H.sub.42-Cl.sub.3 7.2-6.5 m (8H); 4.9 t (1H); 3.8-3.0 m         (4H);     2.9-2.4 m (4H); 2.2 s (3H);         4.0 q (2H); 1.9-1.4 m (2H); 1.2 t          (3H); 1.0 d (6H) 191 1 H H " CH.sub.2CCH H CH.sub.2CH.sub.2CH.sub.3     7.2-6.5 m (4H); 4.9 t (1H); 3.8-3.0 m         (5H); 2.9-2.6 m (2H);     1.9-1.4 m (5H);         1.0 t (3H) 192 1 H C.sub.2      H.sub.5 " CH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.2CH.sub.2CH(CH.sub.3).sub.2      7.2-6.5 m (4H); 5.8 m (1H); 5.0-4.2 m         (5H); 3.8-3.0 m (3H);     2.9-2.6 m (2H);         4.2 q (2H); 1.9-1.4 m (5H); 1.2 t         (3H);     1.0 d (6H)       193 1 H H "     ##STR64##      H CH.sub.2 SC.sub.6 H.sub.5 7.3-6.5 m (9H); 4.9 t (1H); 3.5-3.0 m(4H);     2.9-2.4 m (4H); 1.0-0.6 m (4H)  194 1 H C.sub.2      H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5     7.2-6.4 m (9H); 4.9 t (1H); 4.2 q (2H)         3.9-3.0 m (6H); 3.0-2.6 m     (2H); 1.9-         1.4 m (2H); 1.2 t (3H); 1.0 d (6H)  195 1 H H "     CH.sub.3 H      ##STR65##      8.0 s (1H); 7.5-6.5 m (9H); 4.9 t(1H); 4.0-3.0 m (3H); 3.0-2.6 m     (4H);2.4 s (3H)  196 1 H C.sub.2 H.sub.5 " C.sub.2      H.sub.5 H     ##STR66##      8.0 s (1H); 7.5-6.5 m (9H); 4.9 t (1H)4.2 q (2H); 3.9-2.9 m (5H);     3.0-2.6 m(4H); 1.1 t (3H)  197 1 H H " C.sub.2      H.sub.5 H     ##STR67##      8.6-6.5 m (8H); 4.9 t (1H); 3.9-2.9 m(5H); 2.9-2.5 m (4H) 1.9-1.4     (2H);1.1 t (3H)  198 1 H H " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 7.2-6.5 m (9H); 4.9 t (1H); 3.9-2.9 m     (5H); 2.9-2.5 m (4H); 1.9-1.4 m (4H);         1.1 t (3H) 199 1 H H "     C.sub.2 H.sub.5 H CH.sub.2 C.sub.6 H.sub.5 7.2-6.5 m (9H); 4.9 t (1H);     3.9-2.9 m         (5H); 2.9-2.5 m (4H); 1.1 t (3H) 200 1 H H " CH(CH.sub.     3).sub.2 CH.sub.3 CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2-6.5 m (9H); 4.9     t (1H); 3.9-2.9 m         (3H); 2.9-2.5 m (4H); 1.9-1.4 m (2H);     1.0 d + t (9H) 201 0 H C.sub.2 H.sub.5 " CH.sub.3 -- CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2-6.5 m (9H); 4.9-4.4 m (2H); 4.2 q         (2H);     2.9-2.5 m (4H); 2.4 s (3H);         1.9-1.4 m (2H); 1.2 t (3H) 202 0 H H     " CH.sub.3 -- CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2-6.5 m (9H); 4.9-4.4     m (2H); 2.9-         2.5 m (4H); 2.4 s (3H); 1.9-1.4 m (2H) 203 0 H     C.sub.2 H.sub.5 " C.sub.2 H.sub.5 -- CH.sub.2 CH.sub.2C.sub.6 H.sub.44-F     7.2-6.5 m (8H); 4.9-4.4 m (2H); 3.8-         3.1 m (2H); 4.2 q (2H);     2.9-2.5 m         (4H); 1.9-1.4 m (2H); 1.2 t (3H);         1.0 t (3H)     204 0 H H " C.sub.2 H.sub.5 -- CH.sub.2CH.sub.2C.sub.6 H.sub.44-F     7.2-6.5 m (8H); 4.9-4.4 m (2H);         3.8-3.1 m (2H); 2.9-2.5 m (4H);            1.9-1.4 m (2H); 1.0 t (3H) 205 0 H C.sub.2      H.sub.5 " CH(CH.sub.3).sub.2 -- CH.sub.2 CH.sub.2C.sub.6      H.sub.44-OCH.sub.3 7.2-6.3 m (8H); 4.9-4.4 m (2H);         4.0-3.6 m     (1H); 4.2 q (2H); 4.0 s         (3H); 2.9-2.5 m (4H); 1.9-1.4 m (2H);          1.2 t (3H); 1.0 d (6H) 206 0 H H " CH(CH.sub.3).sub.2 -- CH.sub.2     CH.sub.2 C.sub.6 H.sub.44-OCH.sub.3 7.2-6.3 m (8H); 4.9-4.4 m (2H); 4.0     s         (3H); 4.0-3.6 m (1H); 2.9-2.5 m (4H);         1.9-1 4 m (2H);     1.0 d (6H) 207 0 H H " CH.sub.2CHCH.sub.2 -- CH.sub.2 CH.sub.2C.sub.6     H.sub.3 (OCH.sub.2 O)3.4 7.2-6.2 m (7H); 5.8 m (1H); 5.0 s (2H)     4.9-4.0 m (6H); 2.9-2.5 m (2H); 1.9-         1.4 m (2H)  208 1 H H      ##STR68##      C.sub.2 H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.4 m     (1H); 3.9-3.0 m(8H); 3.2 s (3H); 2.9-2.5 m (2H);1.9-1.4 m (12H); 1.1 t     (3H)  209 1 H C.sub.2 H.sub.5 " C.sub.2      H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.4 m (1H);     4.2 q         (2H); 3.2 s (3H); 3.9-3.0 m (8H);         2.9-2.5 m (2H);     1.9-1.4 m (12H); 1.3 t         (3H); 1.1 t (3H) 210 1 H H " CH.sub.3 H     CH.sub.2CH.sub.2C.sub.6 H.sub.44-F 7.4-6.9 m (4H); 4.7-4.4 m (1H); 3.9-            3.0 m (6H); 3.2 s (3H); 2.9-2.5 m (2H)         2.3 s (3H);     1.9-1.4 m (12H) 211 1 H C.sub.2      H.sub.5 " CH.sub.3 H CH.sub.2CH.sub.2C.sub.6 H.sub.44-F 7.4-6.9 m (4H);     4.7-4.4 m (1H);         3.9-3.0 m (6H); 3.2 s (3H); 4.2 q         (2H);     2.9-2.5 m (2H); 2.3 s (3H);         1.9-1.4 m (12H); 1.2 t (3H) 212 1 H     H " C.sub.2 H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.42-OCH.sub.3 7.0-6.5     m (4H); 4.7-4.4 m (1H); 3.9 s         (3H); 3.9-3.0 m (8H); 3.2 s (3H);            2.9-2.5 m (2H); 1.9-1.4 m (12H); 1.0 t         (3H) 213 1 H     C.sub.2 H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2CH.sub.2C.sub.6      H.sub.32.6-Cl.sub.2 7.2-6.9 m (3H); 4.7-4.4 m (1H);         4.0-3.1 m     (7H); 4.2 q (2H); 3.2 s         (3H); 2.9-2.5 m (2H); 1.9-1.4 m (12H)          1.2 t (3H); 1.0 d (6H); 214 1 H H " CH(CH.sub.3).sub.2 H CH.sub.2     NHCOC.sub.6 H.sub.5 7.8-7.3 m (5H); 4.7-4.4 m (1H); 3.9-         3.0 m     (9H); 3.2 s (3H); 1.9-1.4 m         (10H); 1.0 d (6H) 215 1 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2 NHCOCH.sub.3 4.7-4.4 m (1H);     4.0-3.0 m (9H);         3.2 s (3H); 2.4 s (3H); 1.9-1.4 m         (10H);     4.2 q (2H); 1.2 t (3H); 1.0 d         (6H)  216 1 H C.sub.2 H.sub.5 "     C.sub.2      H.sub.5 H     ##STR69##      4.7-4.4 m (1H); 4.2 q (2H); 3.8-3.0 m(8H); 3.2 s (3H); 1.9-1.4 m     (23H);1.2 t (3H); 1.0 t (3H)      217 1 H H " CH.sub.2CHCH.sub.2 H     ##STR70##      8.0 s (1H); 7.6-6.6 m (5H); 5.8 m(1H); 5.0 m (5H); 4.7-4.4 m (1H);3.9-3.     0 m (6H); 2.9-2.4 m (2H); 3.2 s(3H); 1.9-1.4 m (10H)  218 1 H H "      ##STR71##      H CH.sub.2 SOC.sub.6 H.sub.5 7.6-7.0 m (5H); 4.7-4.4 m (1H);3.9- 2.9 m     (9H); 3.2 s (3H); 1.9-1.4 m(16H)  219 1 H H " CH.sub.2CCH H CH.sub.2     NHC.sub.6 H.sub.5 7.2-6.5 m (5H); 4.7-4.0 m (3H);         3.8-2.9 m     (6H); 2.9-2.6 m (2H); 3.2 s         (3H); 1.9-1.4 m (11H) 220 1 H     C.sub.2 H.sub.5 " CH.sub.2CCCH.sub.3 H CH.sub.2 CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2 s (5H); 4.7-4.0 m (3H); 4.2 q (2H)         3.8-2.9 m     (6H); 3.2 s (3H); 2.9-2.4 m         (2H); 1.9-1.3 m + s (17H); 1.2 t     (3H)      221 1 H H     ##STR72##      C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2-6.3 m (8H); 4.9     t (1H); 3.9 s (3H); 3.9-3.0 m (5H); 2.9-2.4 m (4H);1.9-1.4 m (2H); 1.1 t     (3H) 222 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2-6.3 m (8H); 4.9 t (1H); 4.2 q (2H)         3.9 s     (3H); 3.9-3.0 m (5H); 2.9-2.5 m         (4H); 1.9-1.4 m (2H); 1.2 t     (3H); 1.0         t (3H) 223 1 H H " CH(CH.sub.3).sub.2 H CH.sub.2     CH.sub.2 C.sub.6 H.sub.44-F 7.2-6.3 m (7H); 4.9 t (1H); 3.9 s     (3H); 3.9-3.0 m (4H); 2.9-2.4 m (4H);         1.9-1.4 m (2H); 1.0 d (6H)     224 1 H C.sub.2 H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2C.sub.6     H.sub.44-F 7.2-6.3 m (7H); 4.9 t (1H); 4.2 q         (2H); 3.9 s (3H);     3.9-3.0 m (4H);         2.9-2.4 m (4H); 1.9-1.4 m (2H); 1.3 t     (3H); 1.0 d (6H);      225 1 H H " CH.sub.3 CH.sub.3     ##STR73##      7.3-6.5 m (6H); 4.9 t (1H); 3.9 s(3H); 3.9-3.0 m (2H); 2.4 s (3H);2.9-2.     4 m (4H); 1.9-1.4 m (2H); 1.0 d(3H)  226 1 H H " C.sub.2 H.sub.5 H     CH.sub.2CH.sub.2C.sub.6 H.sub.32.6-Cl.sub.2 7.3-6.3 m (6H); 4.9 t (1H);     3.9 s (3H)         3.9-3.0 m (5H); 2.9-2.4 m (4H); 1.9-         1.4 m     (2H); 1.2 t (3H) 227 1 H H " CH.sub.2 CH.sub.2      CH.sub.3 H CH.sub.2CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.3-6.3 m (7H);     4.9 t (1H); 3.9 s (3H)         3.9-3.0 m (5H); 2.9- 2.4 m (4H); 2.2 s          (3H); 1.9-1.4 m (4H); 1.0 t (3H) 228 1 H H " CH.sub.2CHCH.sub.2 H     CH.sub.2CH.sub.2C.sub.6 H.sub.3(OCH.sub.3).sub.23.4 7.4-6.1 m (6H); 5.8     m (1H); 5.0-4.3 m         (5H); 3.9 s (9H); 3.9-3.0 m (3H);     2.9-2.4 m (4H); 1.9-1.4 m (2H)  229 1 H C.sub.2      H.sub.5 "     ##STR74##      H CH.sub.2 CH.sub.2C.sub.6 H.sub.42-Cl4-NO.sub.2 8.2-6.4 m (7H); 4.9 t     (1H); 4.2 q (2H)3.9 s (3H); 3.9-3.0 m (4H); 2.9-2.4 m(4H); 1.9-1.2 m     (8H); 1.2 t (3H)  230 1 H H " C.sub.2      H.sub.5 H     ##STR75##      7.4-6.3 m (8H) 4.9 t (1H); 3.9 s (3H)3.9-3.0 m (5H); 2.9-2.4 m (4H);1.1     t (3H)  231 1 H H " C.sub.2 H.sub.5 H CH.sub.2CH.sub.2CH(CH.sub.3).sub.2     7.3-6.4 m (8H); 4.9 t (1H); 3.9 s (3H)         3.9-3.0 m (5H); 2.9-2.6 m     (2H); 1.9-         1.4 m (5H); 1.2 t (3H); 1.0 d (6H) 232 1 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.3 7.3-6.4 m (3H); 4.9 t     (1H); 4.2 q         (2H); 3.9 s (3H); 3.9-3.0 m (4H); 2.9-         2.6 m     (2H); 1.9-1.4 m (2H); 1.2 t         (3H); 1.0 d + t (9H) 233 1 H C.sub.2     H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 SC.sub.6 H.sub.5 7.3-6.4 m     (8H); 4.9 t (1H); 4.2 q         (2H); 3.9 s (3H); 3.9-3.0 m (5H);      2.9-2.6 m (2H); 1.9-1.4 m (2H); 1.2 t         (3H); 1.0 t (3H) 234 1 H     H " CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.2     NHCOC.sub.6 H.sub.5 7.6-6.4 m (8H); 4.9 t (1H); 3.9 s         (3H);     3.9-3.0 m (6H); 3.0-2.7 m (2H);         1.9-1.4 m (6H); 1.0 d + t (6H)     235 1 H C.sub.2 H.sub.5 " CH.sub.3 CH.sub.3 n-C.sub.6 H.sub.13 7.3-6.5 m     (3H); 4.9 t (1H); 4.2 q         (2H); 3.9 s (3H); 3.9-3.0 m (2H);      2.9-2.6 m (2H); 2.4 s (3H); 1.9-1.4 m         (10H); 1.2 t (3H); 1.0 d     + t (6H) 236 0 H H " C.sub.2 H.sub.5 -- CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 7.2-6.4 m (8H); 4.9-4.4 m (2H); 3.9 s         (3H); 3.9-3.0 m     (2H); 3.0-2.6 m (4H);         1.9-1.4 m (2H); 1.0 t (3H) 237 0 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 -- CH.sub.2 CH.sub.2C.sub.6 H.sub.44-F     7.3-6.4 m (7H); 4.9-4.4 m (2H); 3.9 s         (3H); 4.2 q (2H); 4.0-3.6     m (1H);         3.0-2.6 m (4H); 1.9-1.4 m (2H); 1.2 t         (3H); 1.0     d (6H) 238 0 H H " CH.sub.2CHCH.sub.2 -- CH.sub.2 CH.sub.2C.sub.6        4     H.sub.4-OCH.sub.3 7.3-6.2 m (7H); 5.8 m (1H); 5.0-4.2 m         (6H);     3.9 s (6H); 3.0-2.6 m (4H);         1.9-1.4 m (2H)      239 0 H H " CH(CH.sub.3).sub.2 --      ##STR76##      7.3-6.4 m (6H); 4.9- 4.4 m (2H); 3.9 s(3H); 3.9-3.5 m (1H); 3.0-2.6 m     (4H);1.9-1.4 m (2H); 1.1 d (6H)  240 0 H C.sub.2      H.sub.5 "     ##STR77##      -- CH.sub.2 CH.sub.2C.sub.6 H.sub.3 (OCH.sub.3).sub.22.5 7.3-6.2 m     (6H); 4.9-4.4 m (2H); 3.9 s(9H); 3.9-3.5 m (1H); 3.0-2.6 m (4H);1.9-1.4     m (8H); 4.2 q (2H); 1.2 t (3H)      241 1 H H     ##STR78##      CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.4 m     (1H); 3.9-3.0 m(4H); 2.9-2.6 m (2H); 2.3 s (3H);1.9-1.4 m (13H)  242 1 H     C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s     (5H); 4.8-4.4 m (1H); 4.2 q (2H)         3.9-3.0 m (4H); 2.9-2.6 m (2H);     2.3 s         (3H); 1.9-1.4 m (13H); 1.2 t (3H) 243 1 H H " C.sub.2     H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.44-F 7.3-6.9 m (4H); 4.8-4.4 m     (1H); 3.9-         3.0 m (6H); 2.9-2.6 m (2H); 1.9-1.4 m         (13H);     1.0 t (3H) 244 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.44-F 7.3-6.9 m (4H); 4.8-4.4 m (1H); 4.2 q         (2H);     3.9-3.0 m (6H); 2.9-2.6 m (2H);         1.9-1.4 m (13H); 1.2 t (3H); 1.0     t (3H) 245 1 H H " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2 C.sub.6        4     H.sub.4-F 7.3-6.9 m (4H); 4.8-4.4 m (1H); 3.9-         3.0 m (5H);     2.9-2.6 m (2H); 1.9-1.4 m         (13H); 1.0 d (6H) 246 1 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2CH.sub.2C.sub.6 H.sub.44-F     7.3-6.9 m (4H); 4.8-4.4 m (1H); 4.2 q         (2H); 3.9-3.0 m (5H);     2.9-2.6 m         (2H); 1.9-1.4 m (13H); 1.2 t (3H);         1.0 d (6H)     247 1 H H " CH.sub.2CHCH.sub.2 H CH.sub.2CH.sub.2C.sub.6      H.sub.44-OCH.sub.3 7.0-6.3 m (4H); 5.8 m (1H); 5.0-4.2 m         (5H);     3.9-3.0 m (4H); 3.9 s (3H);         2.9-2.6 m (2H); 1.9-1.4 m (13H) 248     1 H C.sub.2 H.sub.5 " CH.sub.2CHCH.sub.2 H CH.sub.2CH.sub.2C.sub.6     H.sub.44-OCH.sub.3 7.0-6.3 m (4H); 5.8 m (1H); 5.0-4.2 m         (5H);     4.2 q (2H); 3.9-3.0 m (4H); 3.9         s (3H); 2.9-2.6 m (2H); 1.9-1.4     m         (13H); 1.2 t (3H) 249 1 H H " C.sub.2      H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.44-OCH.sub.3 7.0-6.3 m (4H);     4.8-4.4 m (1H); 3.9-         3.0 m (6H); 2.9-2.4 m (4H); 1.9-1.4 m       (13H); 1.0 t (3H) 250 1 H C.sub.2 H.sub.5 " C.sub.2      H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.44-OCH.sub.3 7.0-6.3 m (4H);     4.8-4.4 m (1H);         4.2 q (2H); 3.9-3.0 m (6H); 2.9-2.4 m     (4H); 1.9-1.4 m (13H); 1.2 t (2H);         1.0 t (3H) 251 1 H H "     C.sub.2 H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.2 s (4H);     4.8-4.4 m (1H); 3.9-3.0 m         (6H); 2.9-2.4 m (4H); 2.1 s (3H); 1.9-             1.4 m (13H); 1.0 t (3H) 252 1 H C.sub.2 H.sub.5 " C.sub.2     H.sub.5 H CH.sub.2CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.2 s (4H); 4.8-4.4     m (1H); 4.2 q (2H)         3.9-3.0 m (6H); 2.9-2.4 m (4H); 2.1 s     (3H); 1.9-1.4 m (13H); 1.2 t (3H);         1.0 t (3H) 253 1 H H "     CH.sub.2CCH H CH.sub.2CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.2 s (4H);     4.8-4.0 m (3H); 3.9-3.0 m         (4H); 2.9-2.4 m (4H); 2.1 s (3H);        1.9-1.4 m (14H); 1.0 t (3H) 254 1 H C.sub.2 H.sub.5 " CH.sub.2CCH H     CH.sub.2 CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.2 s (4H); 4.8-4.0 m (5H);     4.2 q (2H)         3.9-3.0 m (4H); 2.9-2.4 m (4H); 2.1 s         (3H);     1.9-1.4 m (14H); 1.2 t (3H);         1.0 t (3H) 255 1 H H " C.sub.2     H.sub.5 H CH.sub.2 SC.sub.6 H.sub.5 7.2 s (5H); 4.8-4.4 m (1H); 3.9-3.0     m         (6H); 2.9-2.4 m (4H); 1.9-1.4 m (11H)         1.1 t (3H) 256 1     H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2 SOC.sub.6 H.sub.5 7.5-7.0     m (5H); 4.8-4.4 m (1H); 4.2 q         (2H); 3.9-3.0 m (6H); 2.9-2.4 m     (4H);         1.9-1.4 m (11H); 1.2 t (3H); 1.0 t         (3H) 257 1 H     C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2 SO.sub.2 C.sub.6 H.sub.5     7.5-7.0 m (5H); 4.8-4.4 m (1H); 4.2         (2H); 3.9-3.0 m (6H);     2.9-2.4 m (4H);         1.9-1.4 m (11H); 1.2 t (3H); 1.0 t         (3H)     258 1 H H " C.sub.2 H.sub.5 H CH.sub.2 NHCOC.sub.6 H.sub.5 7.7-7.2 m     (5H); 4.7-4.4 m (1H); 3.9-         3.0 m (8H); 2.9-2.4 m (2H); 1.9-1.4 m             (11H); 1.0 t (3H) 259 1 H H " C.sub.2 H.sub.5 H CH.sub.2     CH.sub.2 NHC.sub.6 H.sub.5 7.1-6.5 m (5H); 4.7-4.4 m (1H); 3.9-     3.0 m (6H); 2.9-2.4 m (4H); 1.9-1.4 m         (13H); 1.0 t (3H)  260 1 H     H " C.sub.2      H.sub.5 H     ##STR79##      7.2-6.8 m (3H); 4.7-4.4 m (1H); 3.9-3.0 m (6H); 2.9-2.4 m (4H); 1.9-1.4     m(13H); 1.0 t (3H)  261 1 H H " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2     CH.sub.2 CH.sub.3 4.7-4.4 m (1H); 3.9-3.0 m (6H);         2.9-2.4 m     (2H); 1.9-1.4 m (17H); 1.0 t         (6H) 262 1 H H " C.sub.2 H.sub.5 H     CH.sub.2 CH.sub.2 C.sub.6 H.sub.3 (OCH.sub.3).sub.23.4 6.9-6.2 m (3H);     4.7-4.4 m (1H); 3.9 s         (6H); 3.9-3.0 m (6H); 2.9-2.4 m (4H);        1.9-1.4 m (13H); 1.0 t (3H) 263 1 H H " C.sub.2 H.sub.5 H CH.sub.2     OC.sub.6 H.sub.5 7.0-6.5 m(5H); 4.7-4.4 m (1H); 3.9-         3.0 m (8H);     2.9-2.4 m (2H); 1.9-1.4 m         (11H); 1.0 t (3H) 264 1 H H "  C.sub.2     H.sub.5 H CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 7.0-6.5 m (5H); 4.7-4.4 m     (1H); 3.9-         3.0 m (8H); 2.9-2.4 m (2H); 1.9-1.4 m         (13H);     1.0 t (3H)      265 1 H H " CH(CH.sub.3).sub.2 H     ##STR80##      8.0 s (1H); 7.6-6.8 m (5H); 4.7-4.4 m(1H); 3.9-3.0 m (5H); 2.9-2.4 m     (4H);1.9-1.4 m (11H); 1.0 d (6H)  266 0 H H " C.sub.2 H.sub.5 H CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.3 m (2H); 3.9-3.0 m     (3H); 2.9-2.4 m (2H); 1.9-1.4 m (13H)         1.0 t (3H) 267 0 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 -- CH.sub.2 CH.sub.2C.sub.6 H.sub.44-F     7.2-6.8 m (4H); 4.8-4.3 m (2H); 4.2 q         (2H); 3.9-3.0 m (2H);     2.9-2.4 m (2H);         1.9-1.4 m (13H); 1.2 t (3H); 1.0 d         (6H)     268 0 H H " CH.sub.2CHCH.sub.2 -- CH.sub.2CH.sub.2C.sub.6      H.sub.5(OCH.sub.2 O)3.4 6.9-6.2 m (3H); 5.8 m (1H); 5.0 s         (2H);     5.0-4.2 m (6H); 3.9-3.4 m (1H);         2.9-2.4 m (2H); 1.9-1.4 m (13H)     269 0 H C.sub.2 H.sub.5 " CH.sub.2 CH.sub.2 CH.sub.3 -- CH.sub.2         C     CH.sub.2.sub.6 H.sub.4OCH.sub.34 7.0-6.4 m (4H); 4.8-4.3 m (2H); 4.2 q           (2H); 3.9-3.0 m (3H); 3.9 s (3H);         2.9-2.5 m (2H); 1.9-1.4     m (15H); 1.2 t         (3H); 1.0 t (3H)      270 0 H H "     ##STR81##      -- CH.sub.2 CH.sub.2 C.sub.6 H.sub.42-CH.sub.3 7.2 s (4H); 4.8-4.3 m     (2H); 3.9-3.1 m(2H); 2.9-2.5 m (2H); 2.1 s (3H);1.9-1.4 m (19H)  271 1 H     H      ##STR82##      C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.4     m (1H); 3.9-3.0 m(7H); 3.2 s (3H); 2.9-2.4 m (2H);1.9-1.4 m (12H); 1.0 t     (3H)  272 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.4 m (1H); 4.2 q         (2H); 3.9-3.0     m (7H); 3.2 s (3H);         2.9-2.4 m (2H); 1.9-1.4 m (12H); 1.2     t (3H); 1.0 t (3H) 273 1 H C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.2     CH.sub.2 C.sub. 6 H.sub.5 7.2 s (5H); 4.8-4.4 m (1H); 4.2 q     (2H); 3.9-3.0 m (5H); 3.2 s (3H); 2.9-         2.4 m (2H); 2.3 s (3H);     1.9-1.4 m         (12H); 1.2 t (3H) 274 1 H H " CH.sub.3 H CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.4 m (1H); 3.9-3.0 m     (5H); 3.2 s (3H); 2.9-2.4 m (2H);         2.3 s (3H); 1.9-1.4 m (12H)     275 1 H H " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2C.sub.6 H.sub.44-F     7.4-6.9 m (4H); 4.8-4.4 m (1H);         3.9-3.0 m (7H); 3.2 s (3H);     2.9-2.4 m         (2H); 1.9-1.4 m (12H); 1.0 t (3H) 276 1 H C.sub.2     H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2C.sub.6 H.sub. 44-F 7.4-6.9     m (4H); 4.8-4.4 m (1H); 3.9-         3.0 m (7H); 4.2 q (2H); 3.2 s (3H);             2.9-2.4 m (2H); 1.9-1.4 m (12H); 1.2 t         (3H); 1.0 t (3H)     277 1 H H " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2C.sub.6 H.sub.44-F     7.4-6.9 m (4H); 4.8-4.4 m (1H); 3.9-         3.0 m (6H); 3.2 s (3H);     2.9-2.4 m         (2H); 1.9-1.4 m (12H); 1.0 d (6H) 278 1 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2C.sub.6 H.sub.44-F     7.4-6.9 m (4H); 4.8-4.4 m (1H); 3.9-         3.0 m (6H); 4.2 q (2H); 3.2     s (3H);         2.9-2.4 m (2H); 1.9-1.4 m (12H);         1.2 t (3H); 1.0     d (6H) 279 1 H C.sub.2 H.sub.5 " CH.sub.2CHCH.sub.2 H CH.sub.2      CH.sub.2C.sub.6 H.sub.44-OCH.sub.3 7.0-6.4 m (4H); 5.8 m (1H); 5.0-4.2     m         (5H); 4.2 q (2H); 3.9 s (3H); 3.9-3.0         m (5H); 3.2 s     (3H); 2.9-2.4 m (2H);         1.9-1.4 m (12H); 1.2 t (3H) 280 1 H H "     CH.sub.2CHCH.sub.2 H CH.sub.2 CH.sub.2C.sub.6 H.sub.44-OCH.sub.3 7.0-6.4     m (4H); 5.8 m (1H); 5.0-4.2 m         (5H); 3.9 s (3H); 3.9-3.0 m (5H);     3.2 s         (3H); 2.9-2.4 m (2H); 1.9-1.4 m (12H) 281 1 H H " C.sub.2     H.sub.5 CH.sub.3 CH.sub.2 CH.sub.2C.sub.6 H.sub.44-OCH.sub.3 7.0-6.4 m     (4H); 4.8-4.4 m (1H); 3.9-         3.0 m (6H); 3.9 s (3H); 3.2 s (3H);           2.9-2.4 m (2H); 1.9-1.4 m (12H); 1.0         d + t (6H) 282 1 H     C.sub.2 H.sub.5 " C.sub.2 H.sub.5 CH.sub.3 CH.sub.2 CH.sub.2C.sub.6     H.sub.44-OCH.sub.3 7.0-6.4 m (4H); 4.8-4.4 m (1H); 4.2 q         (2H);     3.9-3.0 m (6H); 3.9 s (3H);         3.2 s (3H); 2.9-2.4 m (2H); 1.9-1.4            m (12H); 1.2 t (3H); 1.0 d + t (6H) 283 1 H H " C.sub.2 H.sub.5 H     CH.sub.2 CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.2 s (4H); 4.8-4.4 m (1H);     3.9-3.0 m         (7H); 3.2 s (3H); 2.9-2.4 m (2H);         2.1 s (3H);     1.9-1.4 m (12H); 1.0 t         (3H) 284 1 H C.sub.2 H.sub.5 "  C.sub.2     H.sub.5 H CH.sub.2 CH.sub.2C.sub.6 H.sub.42-CH.sub.2 7.2 s (4H); 4.8-4.4     m (1H); 4.2 q         (2H); 3.9-3.0 m (7H); 3.2 s (3H);         2.9-2.4     m (2H); 2.1 s (3H); 1.9-1.4 m         (12H); 1.2 t (3H); 1.0 t (3H) 285     1 H H " CH.sub.2CCH H CH.sub.2 CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.2 s     (4H); 4.8-4.4 m (1H); 4.3-3.0 m         (7H); 3.2 s (3H); 2.9-2.4 m     (2H);         2.1 s (3H); 1.9-1.4 m (13H) 286 1 H C.sub.2 H.sub.5 "     CH.sub.2CCH H CH.sub.2 CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.2 s (4H);     4.8-4.4 m (1H); 4.3-3.0 m         (9H); 3.2 s (3H); 2.9-2.4 m (2H);        2.1 s (3H); 1.9-1.4 m (13H); 1.2 t         (3H) 287 1 H H " C.sub.2     H.sub.5 H CH.sub.2 SC.sub.6 H.sub.5 7.2 s (5H); 4.8-4.4 m (1H); 3.9-3.0     m         (7H); 3.2 s (3H); 2.9-2.4 m (2H);         1.9-1.4 m (10H); 1.0     t (3H) 288 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2 SOC.sub.6     H.sub.5 7.4-7.0 m (5H); 4.8-4.4 m (1H); 4.2 q         (2H); 3.9-3.0 m     (7H); 3.2 s (3H);         2.9-2.4 m (2H); 1.9-1.4 m (10H); 1.2 t     (3H); 1.0 t (3H) 289 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2     SO.sub.2 C.sub.6 H.sub.5 7.6-7.0 m (5H); 4.8-4.4 m (1H);         4.2 q     (2H); 3.9-3.0 m (7H); 3.2 s         (3H); 3.1-2.6 m (2H); 1.9-1.4 m     (10H);         1.2 t (3H); 1.0 t (3H) 290 1 H H " C.sub.2 H.sub.5 H     CH.sub.2 NHCOC.sub.6 H.sub.5 7.9-7.3 m (5H); 4.8-4.4 m (1H); 3.9-      2.8 m (9H); 3.2 s (3H); 1.9-1.4 m         (10H); 1.0 t (3H) 291 1 H H "     C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 NHC.sub.6 H.sub.5 7.0-6.4 m (5H);     4.8-4.4 m (1H); 3.9-         2.8 m (9H); 3.2 s (3H); 1.9-1.4 m     (12H); 1.0 t (3H)  292 1 H H " C.sub.2      H.sub.5 H     ##STR83##      7.2-6.7 m (3H); 4.8-4.4 m (1H); 3.9-3.1 m (7H); 3.2 s (3H); 2.9- 2.5 m     (2H);1.9-1.4 m (12H); 1.0 t (3H) 293 1 H H " C.sub.2 H.sub.5 H CH.sub.2     CH.sub.2 CH.sub.3 4.8-4.4 m (1H); 3.9-3.1 m (7H); 3.2 s         (3H);     1.9-1.4 m (14H); 1.0 t (6H) 294 1 H H " C.sub.2 H.sub.5 CH.sub.3     CH.sub.2 CH.sub.2CH(CH.sub.3).sub.2 4.8-4.4 m (1H); 3.9-3.1 m (6H); 3.2     s         (3H); 1.9-1.4 m (15H); 1.0 t + d (12H)      295 1 H H "     ##STR84##      H CH.sub.2 CH.sub.2C.sub.6 H.sub.3 (OCH.sub.3).sub.23.4 6.9-6.2 m (3H);     3.9 s (6H); 3.9-3.1 m(6H); 3.2 s (3H); 2.9-2.4 m (2H); 1.9-1.4 m (20H)     296 1 H H " CH(CH.sub.3).sub.2 H CH.sub.2 OC.sub.6 H.sub.5 7.0-6.6 m     (5H); 3.9-3.1 m (8H); 3.2 s         (3H); 1.9-1.4 m (10H); 1.0 d (6H)     297 1 H H " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 7.1-6.6     m (5H); 4.8-4.4 m (1H);         3.9-3.1 m (9H); 3.2 s (3H); 2.0-1.3 m          (12H); 1.0 t (3H)      298 1 H H " CH.sub.3 H     ##STR85##      8.0 s (1H); 7.6-6.7 m (5H); 4.8-4.4 m(1H); 3.9-3.1 m (5H); 3.2 s (3H);     2.9-2.4 m (2H); 2.3 s (3H); 1.9-1.4 m(10H)      299 1 H H " CH(CH.sub.3).sub.2 H      ##STR86##      8.6-7.4 m (4H); 4.8-4.4 m (1H); 3.9-3.1 m (6H); 3.2 s (3H); 2.9-2.4     m(2H); 1.9-1.4 m (12H); 1.0 d (6H)      300 1 H H " CH.sub.3 H     ##STR87##      7.3 s (5H); 4.8-4.4 m (1H); 3.9-3.1 m(5H); 3.2 s (3H); 2.9-2.4 m (2H);     2.3 s (3H); 2.1 s (3H); 1.9-1.4 m(12H)  301 0 H H " C.sub.2 H.sub.5 --     CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.3 m (2H); 3.9-3.1 m            (4H); 3.2 s (3H); 2.9-2.4 m (2H);         1.9-1.4 m (12H); 1.0 t     (3H) 302 0 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 -- CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.3 m (2H); 4.2 q         (2H); 3.9-3.1     m (4H); 3.2 s (3H);         2.9-2.4 m (2H); 1.9-1.4 m (12H); 1.2 t       (3H); 1.0 t (3H) 303 0 H H " C.sub.2 H.sub.5 -- CH.sub.2      CH.sub.2C.sub.6 H.sub.44-F 7.4-6.9 m (4H); 4.8-4.3 m (2H);     3.9-3.1 m (4H); 3.2 s (3H); 2.9-2.4 m         (2H); 1.9-1.4 m (12H); 1.0     t (3H) 304 0 H C.sub.2 H.sub.5 " CH(CH.sub.3).sub.2 -- CH.sub.2 CH.sub.2     C.sub.6 H.sub.3 (OCH.sub.2 O)3.4 6.9-6.2 m (3H); 5.0 s (2H); 4.8-4.3 m           (2H); 4.2 q (2H); 3.9-3.1 m (3H);         3.2 s (3H); 2.9-2.4 m     (2H); 1.9-1.4 m         (12H); 1.0 d (6H) 305 0 H H " CH.sub.2CHCH.sub.2     -- CH.sub.2CH.sub.2C.sub.6 H.sub.32.6-Cl 7.4-7.0 m (3H); 5.8 m (1H);     5.0-4.1 m         (6H); 3.9-3.1 m (2H); 3.2 s (3H);         2.9-2.4 m     (2H); 1.9-1.4 m (12H) 306 0 H C.sub.2 H.sub.5 " CH.sub.2 CH.sub.2     CH.sub.3 -- CH.sub.2 CH.sub.2C.sub.6 H.sub.4OCH.sub.3 7.0-6.4 m (4H);     4.8-4.3 m (2H); 4.2 q         (2H); 3.9-3.1 m (4H); 3.9 s (3H);     3.2 s (3H); 2.9-2.4 m (2H); 1.9-1.4 m         (14H); 1.2 t (3H); 1.0 t     (3H)      307 0 H H " CH.sub.2CCH --     ##STR88##      7.2-6.7 m (3H); 4.8-4.0 m (4H); 3.9-3.1 m (2H); 3.2 s (3H); 2.9-2.4     m(2H); 1.9-1.4 m (13H)      308 0 H H "     ##STR89##      -- CH.sub.2 CH.sub.2 C.sub.6 H.sub.3Cl4-CN 7.9-7.4 m (3H); 4.8-4.3 m     (2H); 3.9-3.1 m (3H); 2.9-2.4 m (2H); 1.9-1.4 m(12H); 1.1-0.6 m (4H)     309 0 H H " CH.sub.3 --      ##STR90##      8.6-7.4 m (4H); 4.8-4.3 m (2H); 3.9-3.1 m (2H); 2.9-2.4 m (2H); 2.3     s(3H); 1.9-1.4 m (12H)      310 1 H H     ##STR91##      CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 13.4 s (1H); 7.7 s (1H);     7.2 s (5H);4.7-4.3 m (3H); 3.9-3.0 m (3H); 2.9-2.4 m (4H); 2.2 s (3H);     1.9-1.4 m (2H)  311 1 H C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 13.4 s (1H); 7.7 s (1H); 7.2 s (5H);         4.7-4.3 m     (3H); 4.2 q (2H); 3.9-3.0 m         (3H); 2.9-2.4 m (4H); 2.2 s (3H);          1.9-1.4 m (2H); 1.2 t (3H) 312 1 H H " C.sub.2 H.sub.5 H CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 13.4 s (1H); 7.7 s (1H); 7.2 s (5H);     4.7-4.3 m (3H); 3.9-3.1 m (5H); 2.9-         2.4 m (4H); 1.9-1.4 m (2H);     1.0 t (3H) 313 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 13.4 s (1H); 7.7 s (1H); 7.2 s (5H);         4.7-4.3 m     (3H); 4.2 q (2H); 3.9-3.1 m         (5H); 2.9-2.4 m (4H); 1.9-1.4 m     (2H);         1.2 t (3H); 1.0 t (3H) 314 1 H H " CH(CH.sub.3).sub.2 H     CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 13.4 s (1H); 7.7 s (1H); 7.2 s (5H);           4.7-4.3 m (3H); 3.9-3.1 m (4H); 2.9-         2.4 m (4H); 1.9-1.4 m     (2H); 1.0 d         (6H) 315 1 H C.sub.2 H.sub.5 " CH(CH.sub.3).sub.2 H     CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 13.4 s (1H); 7.7 s (1H); 7.2 s (5H);           4.7-4.3 m (3H); 4.2 q (2H); 3.9-3.0 m         (4H); 2.9-2.4 m     (4H); 1.9-1.4 m (2H);         1.2 t (3H); 1.0 d (6H) 316 1 H H "     CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.44-F 13.4 s     (1H); 7.7 s (1H); 7.4-6.9 m         (4H); 4.7-4.3 m (3H); 3.9-3.0 m     (5H);          2.9-2.4 m (4H); 1.9-1.4 m (4H); 1.0 t         (3H) 317 1     H H " CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6     H.sub.3(OCH.sub.3).sub.23.4 13.4 s (1H); 7.7 s (1H); 6.9-6.2 m     (3H); 4.7-4.3 m (3H); 3.9-3.0 m (5H);         3.9 s (6H); 2.9-2.4 m     (4H); 1.9-1.4         m (6H); 1.0 t (3H)      318 1 H H "     ##STR92##      H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 13.4 s (1H); 7.7 s (1H); 4.7-4.3  (     m3H); 3.9-3.0 m (4H); 2.9-2.4 m (2H);1.9-1.4 m (6H); 1.1-0.5 t + m (7H)     319 1 H H " CH.sub.2CCH H CH.sub.2SC.sub.6 H.sub.5 13.4 s (1H); 7.7 s     (1H); 7.2 s (5H);         4.8-4.0 m (5H); 3.9-3.0 m (3H); 2.9-     2.4 m (4H); 1.8 s (1H) 320 1 H H " CH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.2     CH.sub.2C.sub.6 H.sub.44-OCH.sub.3 13.4 s (1H); 7.7 s (1H); 6.8-6.3 m          (4H); 5.8 m (1H); 5.0-4.1 m (7H);         3.9 s (3H); 3.9-3.0 m     (2H); 2.9-2.4 m         (4H); 1.0 d (3H) 321 1 H C.sub.2 H.sub.5 "     C.sub.2 H.sub.5 H CH.sub.2 NHCOC.sub.6 H.sub.5 13.4 s (1H); 7.9-7.4 m     (6H); 4.7-4.3 m         (3H); 4.2 q (2H); 3.9-3.1 m (7H);     2.9-2.5 m (2H); 1.3 t (3H); 1.0 t         (3H) 322 1 H H " C.sub.2     H.sub.5 H CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 13.4 s (1H); 7.7 s (1H);     7.1-6.6 m         (5H); 4.7-4.3 m (3H); 3.9-3.1 m (7H);         2.9-2.5     m (2H); 1.9-1.4 m (2H); 1.0 t         (3H)      323 1 H H     ##STR93##      CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.9 m (7H); 4.9-4.4 m     (3H);3.9-3.1 m (3H); 3.0-2.4 m (4H);2.3 s (3H); 1.9-1.4 m (2H)  324 1 H     C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.9 m     (7H); 4.9-4.4 m (3H);         4.2 q (2H); 3.9-3.1 m (3H); 3.0-     2.4 m (4H); 2.3 s (3H); 1.9-1.4 m         (2H); 1.2 t (3H) 325 1 H H "     C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.9 m (7H);     4.9-4.4 m (3H);         3.9-3.1 m (5H); 3.0-2.4 m (4H);         1.9-1.4     m (2H); 1.0 t (3H) 326 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 7.3-6.9 m (7H); 4.9-4.4 m (3H);         4.2 q     (2H); 3.9-3.1 m (5H); 3.0-         2.4 m (4H); 1.9-1.4 m (2H); 1.2 t         (3H); 1.0 t (3H) 327 1 H H " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.3-6.9 m (7H); 4.9-4.4 m (3H);         3.9-3.1 m (4H);     3.0-2.4 m (4H);         1.9-1.4 m (2H); 1.0 d (6H) 328 1 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.9     m (7H); 4.9-4.4 m (3H);         4.2 q (2H); 3.9-3.1 m (4H); 3.0-     2.4 m (4H); 1.9-1.4 m (2H); 1.2 t         (3H); 1.0 d (6H) 329 1 H H "     CH.sub.2CHCH.sub.2 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.9 m (7H);     5.8 m (1H); 5.0-4.2         m (7H); 3.9-3.1 m (3H); 3.0-2.4 m     (4H); 1.9-1.4 m (2H) 330 1 H H " CH.sub.2CCH H CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 7.3-6.9 m (7H); 5.0-4.2 m (5H);         3.9-3.1 m (3H); 3.0-2.4     m (4H);         1.9-1.4 m (3H)      331 1 H H "     ##STR94##      H CH.sub.2 CH.sub.2 C.sub.6      H.sub.5 7.3-6.9 m (7H); 4.8-4.3 m (3H);3.9-3.1 m (4H); 3.0-2.4 m     (4H)1.9-1.2 m (8H)      332 1 H H     ##STR95##      CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.9 m (7H); 4.9-4.4 m     (3H);3.9-3.0 m (3H); 3.0-2.4 m (4H);2.3 s (3H); 1.9-1.4 m (2H)  333 1 H     H " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.9 m (7H);     4.9-4.4 m (3H);         3.9-3.1 m (5H); 3.0-2.4 m (4H);         1.9-1.4     m (2H); 1.0 t (3H) 334 1 H C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 7.3-6.9 m (7H); 4.9-4.4 m (3H);         4.2 q     (2H); 3.9-3.1 m (3H); 3.0-2.4         m (4H); 2.3 s (3H); 1.9-1.4 m     (2H);         1.2 t (3H) 335 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H     CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.9 m (7H); 4.9-4.4 m (3H);     4.2 q (2H); 3.9-3.1 m (5H); 3.0-2.4         m (4H); 1.9-1.4 m (2H); 1.2     t (3H);         1.0 t (3H) 336 1 H H " CH(CH.sub.3).sub.2 H CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 7.3-6.9 m (7H); 4.9-4.4 m (3H);         3.9-3.1     m (4H); 3.0-2.4 m (4H);         1.9-1.4 m (2H); 1.0 d (6H) 337 1 H     C.sub.2 H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5     7.3-6.9 m (7H); 4.9-4.4 m (3H);         4.2 q (2H); 3.9-3.1 m (4H); 3.0-             2.4 m (4H); 1.9-1.4 m (2H); 1.2 t         (3H); 1.0 d (6H) 338 1     H H " CH.sub.2CHCH.sub.2 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.9 m     (7H); 5.8 m (1H); 5.0-         4.2 m (7H); 3.9-3.1 m (3H); 3.0-     2.4 m (4H); 1.9-1.4 m (2H) 339 1 H H " CH.sub.2CCH H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.3-6.9 m (7H); 5.0-4.2 m (5H);         3.9-3.1 m (4H);     3.0-2.4 m (4H);         1.9-1.4 m (3H)      340 1 H H "     ##STR96##      H CH.sub.2 CH.sub.2 C.sub.6      H.sub.5 7.3-6.9 m (7H); 4.8-4.3 m (3H);3.9-3.1 m (4H); 3.0-2.4 m     (4H);1.9-1.4 m (10H)      341 1 H H     ##STR97##      CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (7H); 4.8-4.4 m     (3H); 3.9-3.1 m (3H); 3.0-2.4 m (4H); 2.3 s(3H); 1.9-1.4 m (2H)  342 1 H     C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s     (7H); 4.8- 4.3 m (3H); 4.2 q         (2H); 3.9-3.1 m (3H); 3.0-2.4 m         (4H); 2.3 s (3H); 1.9-1.4 m (2H);        1.2 t (3H) 343 1 H H "     C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (7H); 4.8-4.3     m (3H); 3.9-3.1         m (5H); 3.0-2.4 m (4H); 1.9-1.4 m         (2H);     1.0 t (3H) 344 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2 s (7H); 4.8-4.3 m (3H); 4.2 q         (2H); 3.9-3.1     m (5H); 3.0-2.4 m         (4H); 1.9-1.4 m (2H); 1.2 t (3H);         1.0     t (3H) 345 1 H H " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 7.2 s (7H); 4.8-4.4 m (3H); 3.9-         3.1 m (4H); 3.0-2.4 m     (4H); 1.9-         1.4 m (2H); 1.0 d (6H) 346 1 H C.sub.2 H.sub.5 "     CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (7H);     4.8-4.4 m (3H); 4.2 q         (2H); 3.9-3.1 m (4H); 3.0-2.4 m     (4H); 1.9-1.4 m (2H); 1.3 t (3H);         1.0 d (6H) 347 1 H H "     n-C.sub.3 H.sub.7 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (7H);     4.8-4.3 m (3H); 3.9-         3.1 m (5H); 3.0-2.4 m (4H); 1.9-     1.4 m (4H); 1.05 t (3H) 348 H H H CH.sub.2CH(OCH.sub.3)CH.sub.2 CH.sub.3     H H 4.8-4.3 m (1H); 3.6-3.0 m + s (7H);         2.3 t (2H); 2.2 s (3H)     1.9-1.3 m (2H) 349 H H C.sub.2 H.sub.5 CH.sub.2CH(OCH.sub.3)CH.sub.2     CH.sub.3 H H 4.8-4.3 m (1H); 4.2 q (2H); 3.6-3.0         m + s (7H); 2.3     t (2H); 2.2 s (3H); 1.9-         1.4 m (2H); 1.2 t (3H) 350 H H H     CH.sub.2CH(OCH.sub.3)CH.sub.2 C.sub.2 H.sub.5 H H 4.8-4.3 m (1H);     3.8-3.0 m + s (9H);         2.3 t (2H); 1.9-1.4 m (2H); 1.2 t (3H) 351 H     H H CH.sub.2CH(OCH.sub.3)CH.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3 4.8-4.3     m (1H); 3.8-2.9 m + s (10H) 1.9-         1.4 m (2H); 1.0 3d (9H) 352 H H     C.sub.2 H.sub.5 CH.sub.2CH(OCH.sub.3)CH.sub.2 C.sub.2 H.sub.5 H CH.sub.3     4.8-4.3 m (1H); 4.2 q (2H); 3.8-2.9         m + s (11H); 1.9-1.4 m (2H);     1.2 t (3H)         1.0 d + t (6H) 353 H H H CH.sub.2CHCH C.sub.2 H.sub.5     H H 6.4-5.5 m (3H); 4.3-3.1 m (6H); 2.3 t         (2H); 1.0 t (3H) 354 H     H C.sub.2 H.sub.5 CH.sub.2CHCH CH.sub.2CHCH.sub.2 H H 6.4-5.5 m (4H);     4.9-3.1 m (10H);         4.2 q (2H); 2.3 t (2H); 1.2 t (3H) 355 H H H     CH.sub.2CHCH C.sub.2 H.sub.5 H CH.sub.3 6.5-5.5 m (3H); 4.3-3.0 m (7H);            1.0 d + t (6H) 356 H H H CH(CH.sub.3)CH.sub.2CH.sub.2 CH.sub.3 H     H 4.8-4.2 m (1H); 3.6-2.9 m (4H); 2.4 s         (3H); 2.3 t (2H);     1.9-1.4 m (3H);         1.0 d (3H) 357 H H C.sub.2      H.sub.5 CH(CH.sub.3)CH.sub.2CH.sub.2 C.sub.2 H.sub.5 H H 4.8-4.3 m     (1H); 4.2 q (2H); 3.8-3.0 m         (6H); 2.3 t (2H); 1.9-1.4 m (3H);     1.2         t (3H); 0.95 d +      t (6H) 358 H H H CH(CH.sub.3)CH.sub.2CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.3 H CH.sub.3 4.8-4.3 m (1H); 3.8-2.9 m (7H); 1.9-         1.4 m     (5H); 1.0 t + 2 d (9H) 359 H H C.sub.2      H.sub.5 CH(CH.sub.3)CH.sub.2CH.sub.2 CH.sub.2CCH H CH.sub.3 4.8-4.0 m     (5H); 3.8-2.9 m (5H); 1.9-         1.4 m (4H); 1.0 2 d (6H) 360 H H H     CH.sub.2 CH(C.sub.6 H.sub.5)CH.sub.2 CH.sub.3 H H 7.3-6.9 m (5H);     4.8-4.3 m (1H); 3.6-         2.9 m (5H); 2.3 t (2H); 2.2 s (3H);     1.9-1.4 m (2H) 361 H H H CH.sub.2 CH(C.sub.6 H.sub.5)CH.sub.2 C.sub.2     H.sub.5 H CH.sub.3 7.3-6.9 m (5H); 4.8-4.3 m (1H); 3.6-         2.8 m     (8H); 1.9-1.4 m (2H); 1.05 d (3H) 362 1 H H CH(C.sub.6      H.sub.5)CH.sub.2CH.sub.2 C.sub.2 H.sub.5 H H 7.3-6.9 m (5H); 4.8-4.3 m     (1H); 3.8-         2.9 m (7H); 2.3 t (2H) 1.9-1.4 m (2H);         1.0 t     (2H) 363 1 H H CH(C.sub.6 H.sub.5)CH.sub.2CH.sub.2 CH(CH.sub.3).sub.2 H     H 7.3-6.9 m (5H); 4.8-4.3 m (1H); 3.8-         2.9 m (6H); 2.3 t (2H)     1.9-1.4 m (2H);         1.0 d (6H)  364 1 H H CH(C.sub.6                 C      H.sub.5)CH.sub.2H.sub.2      ##STR98##      H CH.sub.3 7.3-6.9 m (5H); 4.8-4.3 m (1H); 3.7-2.8 m (7H); 1.9-1.3 m     (8H); 1.0 d (3H)  365 1 H C.sub.2 H.sub.5 (CH.sub.2).sub.4 CH.sub.3 H H     4.8-4.3 m (1H); 3.6-2.8 m (4H); 4.2 q         (2H); 2.4 s (3H); 2.3 t     (2H); 1.9-1.4         m (6H); 1.2 t (3H) 366 1 H H (CH.sub.2).sub.4     CH.sub.3 H CH.sub.3 4.8-4.3 m (1H); 3.6-2.8 m (5H); 2.4 s         (3H);     1.9-1.4 m (6H); 1.1 d (3H) 367 1 H H (CH.sub.2).sub.4 C.sub.2 H.sub.5 H     H 4.8-4.3 m (1H); 3.6-2.8 m (6H); 2.3 t         (2H); 1.9-1.4 m (6H);     1.1 t (3H) 368 1 H H (CH.sub.2).sub.4 CH(CH.sub.3).sub.2 H CH.sub.3     4.8-4.3 m (1H); 3.8-2.8 m (6H); 1.9-         1.4 m (6H); 1.0 d (9H) 369     1 H C.sub.2 H.sub.5 (CH.sub.2).sub.4 CHCCH H H 4.8-4.2 m (3H); 3.8-2.9 m     (4H); 4.2 q         (2H); 2.3 t (2H); 1.9-1.4 m (7H); 1.2         t (3H)     370 1 H H (CH.sub.2).sub.4 C.sub.4 H.sub.9 H CH.sub.3 4.8-4.3 m (1H);     3.8-2.9 m (7H); 1.9-         1.4 m (10H); 1.0 d + t (6H) 377 1 H H     (CH.sub.2).sub.5 CH.sub.3 H H 4.8-4.3 m (1H); 3.6-2.8 m (4H); 2.4 s        (3H); 2.3 t (2H); 1.9-1.4 m (8H) 378 1 H C.sub.2      H.sub.5 (CH.sub.2).sub.5 CH.sub.3 H H 4.8-4.0 m (3H); 3.6-2.8 m (4H);     2.4 s         (3H); 2.3 t (2H); 1.9-1.4 m (8H);         1.2 t (3H) 379 1     H H (CH.sub.2).sub.5 C.sub.2 H.sub.5 H H 4.8-4.3 m (1H); 3.8-2.8 m (6H);     2.3 t         (2H); 1.9-1.4 m (8H); 1.0 t (3H) 380 1 H C.sub.2 H.sub.5     (CH.sub.2).sub.5 C.sub.2 H.sub.5 H H 4.8-4.3 m (1H); 4.2 q(2H); 3.8-2.8     m         (6H); 2.3 t (2H); 1.9-1.4 m (8H); 1.2         t (3H); 1.0 t     (3H) 381 1 H H (CH.sub.2).sub.5 CH(CH.sub.3).sub.2 H CH.sub.3 4.8-4.3 m     (1H); 3.8-2.8 m (6H); 1.9-         1.4 m (8H); 1.0 3d (9H) 382 1 H H     (CH.sub.2).sub.5 CH.sub.2CHCH.sub.2 H CH.sub.3 5.8m (1H); 5.0-4.1 m     (5H); 3.8-2.9 m         (5H); 1.9-1.4 m (8H); 1.0 d (3H)  383 1 H     C.sub.2      H.sub.5 (CH.sub.2).sub.5     ##STR99##      H CH.sub.3 4.7-4.3 m (1H); 4.2q (2H); 3.7-3.0 m(6H); 1.9-1.4 m (8H);     1.0-0.5 d + m(7H); 1.2 t (3H)  384 1 H H (CH.sub.2).sub.5 n-C.sub.4     H.sub.9 H H 4.7-4.3 m (1H); 3.9-3.0 m (6H); 2.3 t         (2H); 1.9-1.4     m (12H); 1.0 t (3H)      385 1 H H     ##STR100##      CH.sub.3 H H 7.1-6.6 m (3H); 4.8-4.3 m (3H); 3.9 s(3H); 3.8-3.0 m (2H);     2.9-2.4 m (4H)2.3 s (3H)  386 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H H     7.1-6.6 m (3H); 4.8-4.3 m (3H); 4.2 q         (2H); 3.9 s (3H); 3.8-3.0     m (4H); 2.9-         2.4 m (4H); 1.2 t (3H); 1.0 t (4H) 387 1 H H "     C.sub.2 H.sub.5 H CH.sub.3 7.1-6.6 m (3H); 4.8-4.3 m (3H); 3.9 s     (3H); 3.8-3.0 m (5H); 2.9-2.4 m (2H);         1.0 d + t (6H) 388 1 H     C.sub.2 H.sub.5 " CH(CH.sub.3).sub.2 H CH.sub.3 7.1-6.6 m (3H); 4.8-4.3     m (3H); 3.9 s         (3H); 3.9-3.1 m (4H); 4.2 q (2H); 2.9-         2.4     m (2H); 1.2 t (3H); 1.0 d (9H) 389 1 H H " CH.sub.2CHCH.sub.2 H CH.sub.3     7.1-6.6 m (3H); 5.8 m (1H); 5.0-4.3         (5H); 3.9 s (3H); 3.8-2.9 m     (3H); 2.8-         2.4 m (2H); 1.05 d (3H)      390 1 H H     ##STR101##      CH.sub.3 H H 4.7-4.3 m (1H); 3.6-2.9 m (4H); 2.3 t(2H); 2.2 s (3H);     1.9-1.4 m (12H)  391 1 H H " C.sub.2 H.sub.5 H H 4.7-4.3 m (1H); 3.8-2.9     m (6H); 2.3 t         (2H); 1.9-1.4 m (12H); 1.1 t (3H) 392 1 H C.sub.2     H.sub.5 " C.sub.2 H.sub.5 H H 4.7-4.3 m (1H); 4.2 q (2H); 3.8-2.9      m (6H); 2.3 t (2H); 1.9-1.4 m (12H);         1.3 t (3H); 1.1 t (3H) 393     1 H H " CH(CH.sub.3).sub.2 H H 4.7-4.3 m (1H); 4.0-3.1 m (5H); 2.3 t         (2H); 1.9-1.4 m (12H); 1.0 d (6H) 394 1 H H " CH.sub.2CHCH.sub.2 H     CH.sub.3 5.8 q (1H); 5.0-4.1 m (5H); 3.8-2.9         m (3H); 1.9-1.4 m     (12H); 1.0 d (3H)      395 1 H H "     ##STR102##       H 4.7-4.3 m (1H); 3.9-2.9 m (5H); 2.3 t(2H); 1.9-1.4 m (18H)  396 1 H     H      ##STR103##      CH.sub.3 H H  7.2-6.6 m (4H); 4.9 t (1H); 3.8-3.1m (2H); 2.9-2.2 m     (4H); 2.3 s (3H)  397 1 H H " C.sub.2 H.sub.5 H H 7.2-6.6 m (4H); 4.9 t     (1H); 3.8-3.1         m (4H); 2.9-2.2 m (4H); 1.1 t (3H) 398 1 H H "     C.sub.2 H.sub.5 H CH.sub.3 7.2-6.6 m (4H); 4.9 t (1H); 3.8-         2.8     m (3H); 2.9-2.2 m (2H); 1.0 t +      d         (6H) 399 1 H H " CH(CH.sub.3).sub.2 H H 7.2-6.6 m (4H); 4.9 t     (1H); 3.9-2.9 m         (3H); 2.9-2.2 m (4H); 1.0 d (6H) 400 1 H H "     CH.sub.2CCH H H 7.2-6.6 m (4H); 4.9 t (1H); 4.3-3.2 m         (4H);     2.9-2.2 m (4H); 1.8 s (1H) 401 1 H H " CH.sub.2 CHCH.sub.2 H CH.sub.3     7.2-6.6 m (4H); 5.8 m (1H); 5.0-4.2 m         (5H); 3.9-2.9 m (3H); 1.0     d (3H)      402 1 H H     ##STR104##      CH.sub.3 H H 4.8-4.3 m (1H); 3.8-2.9 m + s (8H);2.3 t (2H); 2.2 s (3H);     1.9-1.4 m(10H)  403 1 H H " C.sub.2 H.sub.5 H H 4.8-4.3 m (1H); 3.8-2.9     m + s (10H);         2.3 t (2H); 1.9-1.4 m (10H); 1.0 t         (3H) 404     1 H H " C.sub.2 H.sub.5 H CH.sub.3 4.8-4.3 m (1H); 3.8-2.8 m + s (11H);            1.9-1.4 m (10H); 1.0 d + t (6H) 405 1 H H " CH(CH.sub.3).sub.2 H     H 4.8-4.3 m (1H); 3.8-2.9 m + s (9H);         2.3 t (2H); 1.9-1.4 m     (10H); 1.0 d         (6H)      406 1 H H "     ##STR105##      H CH.sub.3 4.8-4.3 m (1H); 3.8-2.9 m + s (10H);1.9-1.4 m (16H); 1.0 d     (6H)      407 1 H H     ##STR106##      CH.sub.3 H H 4.9-4.4 m(1H); 4.0-3.1 m (3H); 2.3 t(2H); 2.2 s (3H);     1.9-1.4 m (11H)  408 1 H H " C.sub.2 H.sub.5 H H 4.9-4.4 m (1H); 4.0-3.1     m (5H); 2.3 t         (2H); 1.9-1.4 m (11H) 1.1 t (3H) 409 1 H H "     CH(CH.sub.3).sub.2 H H 4.9-4.4 m (1H); 4.0-3.1 m (4H); 2.3 t     (2H); 1.9-1.4 m (11H); 1.0 d (6H) 410 1 H H " C.sub.2 H.sub.5 H CH.sub.3     4.9-4.4 m (1H); 4.0-3.0 m (7H); 1.9-         1.4 m (11H); 1.0 d + t (6H)     411 1 H H " CH.sub.2CHCH.sub.2 H CH.sub.3 5.8 m (1H); 5.1-4.3 m (5H);     4.0-3.2 m         (4H); 1.9-1.4 m (11H); 1.0 d (3H)      412 1 H H     ##STR107##      CH.sub.3 H H 4.9-4.4 m (1H); 4.0-3.1 m + s (7H); 2.4s (3H); 2.3 t (2H);     1.9-1.4 m (9H)  413 1 H H " C.sub.2 H.sub.5 H H 4.9-4.4 m (1H); 4.0-3.1     m + s (9H); 2.3         t (2H); 1.9-1.4 m (9H); 1.0 t (3H) 414 1 H H "     CH(CH.sub.3).sub.2 H H 4.9-4.4 (1H); 4.0-3.1 m + s (8H);         2.3 t     (2H); 1.9-1.4 m (9H); 1.0 d (6H) 415 1 H H " C.sub.2 H.sub.5 H CH.sub.3     4.9-4.4 m (1H); 4.0-3.0 m + s (11H);         1.9-1.4 m (9H); 1.0 d + t     (6H) 416 1 H H " CH(CH.sub.3).sub.2 H CH.sub.3 4.9-4.4 m (1H); 4.0-3.0 m     + s (10H);         1.9-1.4 m (9H); 1.0 d (9H)      417 1 H H     ##STR108##      CH.sub.3 H H 13.4 s (1H); 7.7 s (1H); 4.9-4.3 m(3H); 3.9-3.1 m (2H);     2.3 t (3H);2,4 s (3H); 2.9-2.4 m (2H)  418 1 H H " C.sub.2 H.sub.5 H H     13.4 s (1H); 7.7 s (1H); 4.8-4.3 m         (3H); 3.8-3.1 m (4H); 2.9-2.5     m (2H);         2.3 t (2H); 1.0 t (3H) 419 1 H H " CH(CH.sub.3).sub.2 H     H 13.4 s (1H); 7.7 s (1H); 4.8-4.3 m         (3H); 4.0-3.1 m (3H);     2.9-2.5 m(2H);         2.3 t (2H); 1.0 d (6H) 420 1 H H " C.sub.2     H.sub.5 H CH.sub.3 13.4 s (1H); 7.7 s (1H); 4.8-4.3 m         (3H);     4.0-3.0 m (5H); 2.9-2.5 m (2H);         1.0 d + t (6H)  421 1 H H "      ##STR109##      H H 13.4 s (1H); 7.7 s (1H); 4.8-4.3 m(3H); 3.7-3.0 m (3H); 2.9-2.5 m     (2H);2.3 t (2H); 1.0-0.5 m (4H)      422 1 H H     ##STR110##      CH.sub.3 H H 7.3-6.9 m (2H); 4.9-4.4 m (3H); 3.9-3.1 m (2H), 2.3 t     (2H); 2.2 s (3H);2.9-2.2 m (2H)  423 1 H H " C.sub.2 H.sub.5 H H 7.3-6.9     m (2H); 4.9-4.4 m (3H); 3.9-         3.1 m (4H); 2.3 t (2H); 2.9-2.4 m           (2H); 1.1 t (3H) 424 1 H H " C.sub.2 H.sub.5 H H 7.3-6.9 m (2H);     4.9-4.4 m(3H); 3.9-         3.0 m (5H); 2.9-2.4 m (2H); 1.1 t + d      (6H) 425 1 H H " CH(CH.sub.3).sub.2 H CH.sub.3 7.3-6.9 m (2H); 4.9-4.4     m (3H);         3.9-3.0 m (4H); 2.9-2.4 m (2H);         1.0 d (9H) 426 1     H H " CH(CH.sub.3).sub.2 H H 7.3-6.9 m (2H); 4.9-4.4 m (3H);     3.9-3.0 m (3H); 2.9-2.4 m (2H);         2.3 t (2H); 1.0 d (6H)  427 1 H     H      ##STR111##      CH.sub.3 H H 7.3-6.9 m (2H); 4.9-4.4 m (3H);3.9-3.1 m (2H); 2.3 t (2H);     2.2 s(3H); 2.9-2.2 m (2H)  428 1 H H " C.sub.2 H.sub.5 H H 7.3-6.9 m     (2H); 4.9-4.4 m (3H);         3.9-, 3.1 m (4H); 2.3 t (2H); 2.9-2.4        m (2H); 1.1 t (3H) 429 1 H H " C.sub.2 H.sub.5 H CH.sub.3 7.3-6.9 m     (2H); 4.9-4.3 m (3H);         3.9-3.0 m (5H); 2.9-2.4 m (2H);     1.1 t + d (6H) 430 1 H H " CH(CH.sub.3).sub.2 H H 7.3-6.9 m (2H);     4.8-4.4 m (3H);         3.8-3.0 m (3H); 2.9-2.4 m (2H);         2.3 t     (2H); 1.0 d (6H) 431 1 H H " CH(CH.sub.3).sub.2 H CH.sub.3 7.3-6.9 m     (2H); 4.9-4.4 m (3H);         3.9-3.1 m (4H); 2.9-2.4 m (2H);     1.0 d (9H)      432 1 H H     ##STR112##      C.sub.2 H.sub.5 H H 7.2 s (2H); 4.9-4.4 m (3H); 3.9-3.1m (4H); 2.3 t     (2H); 2.9-2.4 m (2H);1.0 t (3H)  433 1 H H " C.sub.2 H.sub.5 H CH.sub.3     7.2s (2H); 4.9-4.4 m (3H); 3.9-3.0 m         (5H); 2.9-2.4 m (2H); 1.1 t     + d (6H)4341HH" CH(CH.sub.3).sub.2HH7.2 s (2H); 4.9-4.4 m (3H); 3.9-3.2            m (3H); 2.9-2.4 m (2H); 2.3 t (2H);         1.0 d (6H) 435 1 H H     " CH(CH.sub.3).sub.2 H CH.sub.3 7.2 s (2H); 4.9-4.4 m (3H); 3.9-3.1        m (4H); 2.9-2.4 m (2H); 1.1 d (9H)      436 1 H H     ##STR113##      CH.sub.3 H H 4.8-4.2 m (3H); 3.6-3.0 m (2H); 2.7-2.2 m (4H); 2.4 s (3H)      437 1 H C.sub.2 H.sub.5 " CH.sub.3 H H 4.8-4.2 m (5H); 3.6-3.0 m (2H);     2.7-         2.2 m (4H); 2.4 s (3H); 1.2 t (3H) 438 1 H H " C.sub.2     H.sub.5 H CH.sub.3 4.8-4.2 m (3H); 3.7-3.0 m (5H); 2.7-         2.4 m     (2H); 1.0 t + d (6H) 439 1 H C.sub.2 H.sub.5 " CH(CH.sub.3).sub.2 H H     4.8-4.4 m (3H); 4.2q (2H); 3.9-         3.0 m (4H); 2.7-2.4 m (2H); 1.0     d         (9H); 1.2 t (3H) 440 1 H H " CH.sub.3 H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 7.2 s (5H); 4.8-4.2 m (3H); 3.9-         3.0 m (3H);     2.9-2.2 m (4H); 1.9-         1.4 m (2H); 2.3 s (3H); 441 1 H C.sub.2     H.sub.5 " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s     (5H); 4.8-4.3 m (3H) 4.2 q         (2H); 3.9-3.0 m (5H); 2.9-2.2 m       (4H); 1.9-1.4 m (2H); 1.2 t (3H);         1.0 t (3H) 442 1 H H "     CH.sub.2 CHCH.sub.2 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.44-F 7.4-6.9 m     (4H); 5.8 m (1H); 5.1-4.2         (5H); 3.9-3.0 m (3H); 2.9-2.2 m      (4H); 1.9-1.4 m (2H) 443 1 H C.sub.2 H.sub.5 " CH.sub.2CCH H CH.sub.2     CH.sub.2 C.sub.6 H.sub.44-OCH.sub.3 6.9-6.3 m (4H); 4.8-4.0 m (5H); 3.9-             3.1 m (3H); 3.9 s (3H); 2.9-2.2 m         (4H); 1.9-1.4 m (3H);     1.2 t (3H);         4.2 q (2H)      444 1 H H "     ##STR114##      CH.sub.3      ##STR115##      8.0 s (1H); 7.6-6.8 m (5H); 4.8-4.0m (3H); 3.8-3.1 m (3H); 2.9-2.2     m(4H); 1.9-1.4 m (6H); 1.0 d (3H)      445 1 H H     ##STR116##      CH.sub.3 H CH.sub.3 5.0-4.3 m (2H); 3.6-3.0 m (3H); 2.9-2.2 m (2H); 2.3     s (3H); 1.2 d(3H); 1.0 d (3H)  446 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5     H C.sub.2 H.sub.5 5.0-4.3 m (2H); 4.2 q (2H); 5.9-3.1         m (5H);     2.9-2.2 (2H); 1.9-1.4 m (2H);         1.2 d + t (6H); 1.0 t (6H) 447 1 H     H " CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H);     5.0-4.3 m (2H); 3.8-3.0         m (4H); 2.9-2.2 m (4H); 1.9-1.4 m      (2H); 1.2 d (3H); 1.0 d (6H) 448 1 H H " C.sub.2 H.sub.5 H CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 7.2 s (5H); 5.0-4.3 m (2H); 3.8-3.0         m     (5H); 2.9-2.2 m (4H); 1.9-1.4 m         (2H); 1.2 d (3H); 1.0 t (3H) 449     1 H H " CH.sub.3 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.44-F 7.4-6.9 m (4H);     5.0-4.3 m (2H);         3.8-3.0 m (3H); 2.9-2.2 m (4H); 2.3         s     (3H); 1.9-1.4 m (2H); 1.2 d (3H) 450 1 H H " C.sub.2 H.sub.5 H H 5.0-4.3     (2H); 3.8-3.0 m (4H); 2.9-         2.2 m (4H); 1.2 d (3H); 1.0 t (3H);     451 1 H H " CH(CH.sub.3).sub.2 H H 5.0-4.3 m (2H); 3.9-3.1 m (3H); 2.9-            2.2 m (4H); 1.2 d (3H); 0.9 d (6H) 452 1 H C.sub.2 H.sub.5 "     CH.sub.3 CH.sub.3 CH.sub.3 5.0-4.3 m (2H); 4.2 q (2H); 3.9-3.1         m     (2H); 2.9-2.2 m (2H); 2.4 s (3H);         1.2 d + t (6H); 1.0 d (6H)     453 1 H H      ##STR117##      CH.sub.3 H H 7.4-6.8 m (5H); 6.0 s (1H); 4.7-4.3m (1H); 3.6-3.0 t (2H);     2.9-2.2 m(4H); 2.4 s (3H)  454 1 H C.sub.2 H.sub.5 " C.sub.2 H.sub.5 H     CH.sub.3 7.4-6.8 m (5H); 6.0 s (1H); 4.7-4.3         (1H); 4.2 q (2H);     3.6-3.0 m (5H);         2.9-2.2 m (2H); 1.2 t (3H); 1.0 d         + t     (3H) 455 1 H H " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5     7.4-6.8 m (10H); 6.0 s (1H); 4.7-         4.3 m (1H); 3.8-3.0 m (5H);     2.9-         2.2 m (4H); 1.9-1.4 m (2H); 1.0 t         (3H) 456 1 H H "     CH(CH.sub.3).sub.2 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.4-6.8 m (10H);     6.0 s (1H); 4.7-4.3         m (1H); 3.8-3.0 m (4H); 2.9-2.2 m     (4H); 1.9-1.4 m (2H); 1.0 d (6H) 457 1 H C.sub.2 H.sub.5 " CH.sub.3 H     CH.sub.2 CH.sub.2 C.sub.6 H.sub.44-F 7.5-6.8 m (9H); 6.0 s (1H); 4.7-4.3             m (1H); 4.2 q (2H); 3.8-3.0 m (3H);         2.9-2.2 m (4H); 2.3     s (3H); 1.9-1.4         m (2H); 1.2 t (3H) 458 1 H H " CH.sub.2 CH.sub.2     CH.sub.3 H CH.sub.2 CH.sub.2C.sub.6 H.sub.42-CH.sub.3 7.5-6.9 m (9H);     6.0 s (1H); 4.7-4.3         m (1H); 3.8-3.0 m (5H); 2.9-2.2 m     (4H); 2.1 s (3H); 1.9-1.4 m (4H);         1.0 t (3H)  459 1 H C.sub.2     H.sub.5 "      ##STR118##      H      ##STR119##      7.5-6.9 m (10H); 6.0 s (1H); 4.7-4.3m (1H); 3.8-3.0 m (4H); 4.2 q     (2H);2.9-2.2 m (4H); 1.2 t (3H); 1.0-0.5m (4H)      460 1 H H     ##STR120##      CH.sub.3 H H 7.1-6.4 m (4H); 6.0 s (1H); 4.7-4.3 m (1H); 3.6-3.0 t     (2H); 2.9-2.2 m (4H); 2.4 s (3H)  461 1 H C.sub.2 H.sub.5 " CH.sub.3 H H     7.1-6.4 m (4H); 6.0 s (1H); 4.7-         4.3 m (1H); 4.2 q (2H); 3.6-3.0     t         (2H); 2.9-2.2 m (4H); 2.4 s (3H);         1.2 t (3H) 462 1 H H     " C.sub.2 H.sub.5 H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.4 m (9H);     6.0 s (1H); 4.7-4.3         m (1H); 3.8-3.0 m (5H); 2.9-2.2 m     (4H); 1.9-1.4 m (2H); 1.0 t (3H) 463 1 H C.sub.2 H.sub.5 " CH.sub.3 H     CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.4 m (9H); 6.0 s (1H); 4.7-4.3          m (1H); 4.2 q (2H); 3.8-3.0 m (3H);         2.9-2.2 m (4H); 1.9-     1.4 m (2H); 2.2         s (3H); 1.2 t (3H) 464 1 H H " CH(CH.sub.3).sub.2      H CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 7.3-6.4 m (9H); 6.0 s (1H); 4.7-4.3             m (1H); 3.8-2.9 m (4H); 2.9-2.2 m         (4H); 1.9-1.4 m (2H);     1.0 d (6H) 465 1 H H " CH.sub.2CHCH.sub.2 H CH.sub.2 CH.sub.2 C.sub.6     H.sub.44-F 7.3-6.4 m (8H); 6.0-5.6 m (2H);         5.0-4.1 m (5H);     3.6-3.1 m (3H);         2.9-2.2 m (4H); 1.9-1.4 m (2H) 466 1 H C.sub.2     H.sub.5 " CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.2 CH.sub.2C.sub.6      H.sub.44-OCH.sub.3 7.1-6.3 m (8H); 6.0 s (1H); 4.7-4.3         m (1H);     4.2 q (2H); 3.9 s (3H);         3.8-3.0 m (5H); 2.9-2.2 m (4H);     1.9-1.4 m (2H); 1.2 t (3H); 1.0 t         (3H) 467 1 H H " C.sub.2     H.sub.5 H C.sub.2 H.sub.5 7.1-6.5 m (4H); 6.0 s (1H); 4.7-4.3         m     (1H); 3.8-3.0 m (5H); 2.9-2.4 m         (2H); 1.9-1.4 m (2H); 1.0 t (6H)     468 1 H H " C.sub.2 H.sub.5 H n-C.sub.4 H.sub.9 7.1-6.5 m (4H); 6.0 s     (1H); 4.7-4.3         m (1H); 3.83.0 m (5H); 2.9-2.4 m         (2H);     1.9-1.4 m (6H); 1.0 t (6H)  469 1 H H " C.sub.2      H.sub.5 H     ##STR121##      7.3-6.5 m (7H); 6.0 s (1H); 4.7-4.3m (1H); 3.8-3.0 m (5H); 2.9-2.4     m(4H); 1.9-1.4 m (2H); 1.0 t (3H)  470 1 H H " C.sub.2 H.sub.5 H     CH.sub.2 CH.sub.2C.sub.6 H.sub.32.6-Cl.sub.2 7.4-6.5 m (7H); 6.0 s (1H);     4.7-         4.3 m (1H); 3.8-3.0 m (5H); 2.9-         2.4 m (4H);     1.9-1.4 m (2H); 1.0 t         (3H)  471 1 H C.sub.2      H.sub.5 "     ##STR122##      CH.sub.3      ##STR123##      8.6-6.5 m (8H); 6.0 s (1H); 4.7-4.3m (1H); 4.2 q (2H); 3.9-3.1 m     (4H);2.9-2.2 m (4H); 1.9-1.4 m (10H);1.2 t (3H); 1.0 d (3H)  472 1 H H "     CH.sub.3 H CH.sub.3 7.1-6.5 m (4H); 6.0 s (1H); 4.7-4.3         m (1H);     3.6-3.1 m (3H); 2.9-2.4 m         (2H); 2.3 s (3H); 1.0 d (3H) 473 1 H     C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.3 7.1-6.5 m (4H); 6.0 s (1H);     4.7-4.3         m (1H); 4.2 q (2H); 3.6-3.1 m (3H);         2.9-2.4 m     (2H); 2.3 s (3H); 1.0 d         (3H)  474 1 H C.sub.2      H.sub.5     ##STR124##      C.sub.2 H.sub.5 H H 13.4 s (1H); 7.7 s (1H); 4.9-4.3 m(3H); 4.2 q (2H);     3.9-3.1 m (4H);2.9-2.5 m (2H); 2.3 t (2H); 1.2 t(3H); 1.0 t (3H)  475 1     H C.sub.2      H.sub.5     ##STR125##      C.sub.2 H.sub.5 H H 7.3-6.9 m (2H); 4.9-4.4 m (3H);4.2 q (2H); 3.9-3.1     m (4H); 2.3 t(2H); 2.9-2.4 m (2H); 1.2 t (3H);1.0 t (3H)  476 1 H     C.sub.2      H.sub.5     ##STR126##      C.sub.2 H.sub.5 H H 7.3-6.9 m (2H); 4.8-4.4 m (3H);4.2 q (2H); 3.9-3.1     m (4H) 2.9-2.5 m(2H); 2.3 t (2H); 1.2 t (3H); 1.0 t(3H)  477 1 H C.sub.2     H.sub.5      ##STR127##      CH.sub.3 H H 4.7-4.3 m (1H); 4.2 q (2H); 3.6-2.9 m(4H), 2.3 t (2H); 2.2     s (3H); 1.9-1.4 m (12H); 1.1 t (3H)  478 1 H C.sub.2 H.sub.5 " C.sub.2     H.sub.5 H CH.sub.3 4.7-4.3 m (1H); 4.2 q (2H); 3.8-2.9 m         (7H);     1.9-1.4 m (12H); 1.2 t         (3H); 1.1 d + t (6H) 479 1 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 H H 4.7-4.3 m (1H); 4.2 q (2H); 4.0-3.1 m           (5H); 2.3 t (2H); 1.9-1.4 m (12H);         1.2 t (3H); 1.0 d (6H)     480 1 H C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.3 4.7-4.3 m (1H); 4.2 q     (2H); 3.8-2.9 m         (5H); 2.2 s (3H); 1.9-1.4 m (12H);         1.2 t     (3H); 1.1 d (3H)  481 1 H C.sub.2      H.sub.5     ##STR128##      CH.sub.3 H H 7.2-6.6 m (4H); 4.9 t (1H); 4.2 q(2H); 3.8-3.1 m (2H);     2.9-2.2 m (4H)2.3 s (3H); 1.2 t (3H)  482 1 H C.sub.2 H.sub.5 " C.sub.2     H.sub.5 H H 7.2-6.6 m (4H); 4.9 t (1H); 4.2 q         (2H); 3.8-3.1 m     (4H); 2.9-2.2 m (4H)         1.2 t (3H); 1.0 t (3H) 483 1 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 H H 7.2-6.6 m (4H); 4.9 t (1H); 4.2 q       (2H); 3.9-2.9 m (3H); 2.9-2.2 m         (4H); 1.2 t (3H); 1.0 d (6H)     484 1 H C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.3 7.2-6.6 m (4H); 4.9 t     (1H); 4.2 q         (2H); 3.8-3.1 m (2H); 2.9-2.3 m (3H)         2.3 s     (3H); 1.2 t (3H); 1.0 d (3H)  485 1 H C.sub.2      H.sub.5     ##STR129##      CH.sub.3 H H 4.8-4.3 m (1H); 4.2 q (2H); 3.8-2.9 m+ s (8H); 2.3 s (3H);     2.2 t (2H); 1.9-1.4 m (10H); 1.2 t (3H)  486 1 H C.sub.2 H.sub.5 "     C.sub.2 H.sub.5 H H 4.8-4.3 m (1H); 4.2 q (2H); 3.8-         2.9 m + s     (10H); 2.2 t (2H);         1.9-1.4 m (10H); 1.2 t (3H); 1.0 t     (3H) 487 1 H C.sub.2 H.sub.5 " CH(CH.sub.3).sub.2 H H 4.8-4.3 m (1H);     4.2 q (2H); 3.9-2.9         m + s (9H); 2.2 t (2H); 1.9-1.4 m     (10H); 1.2 t (3H); 0.9 d (6H) 488 1 H C.sub.2 H.sub.5 " CH.sub.3 H     CH.sub.3 4.8-4.3 m (1H); 4.2 q (2H); 3.9-2.9 m         + s (9H); 2.3 s     (3H); 1.9-1.4 m         (10H); 1.2 t (3H); 1.0 d (3H)  489 1 H C.sub.2     H.sub.5      ##STR130##      CH.sub.3 H H 4.9-4.4 m (1H); 4.2 q (2H); 4.0-3.1 m(3H); 2.3 t (2H); 2.2     s (3H); 1.9-1.4 m (11H); 1.2 t (3H)  490 1 H C.sub.2 H.sub.5 " C.sub.2     H.sub.5 H H 4.9-4.4 m (1H); 4.2 q (2H); 4.0-3.1 m         (5H); 2.3 t     (2H); 1.9-1.4 m (11H);         1.2 t (3H); 1.0 t (3H) 491 1 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 H H 4.9-4.4 m (1H); 4.2 q (2H); 4.0-3.1         m (4H); 2.3 t (2H); 1.9-1.4 m (11H);         1.2 t (3H); 1.05 d (6H)     492 1 H C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.3 4.9-4.4 m (1H); 4.2 q     (2H); 4.0-3.0 m         (4H); 2.2 s (3H); 1.9-1.4 m (11H);         1.2 t     (3H); 1.0 d (3H)  493 1 H C.sub.2      H.sub.5     ##STR131##      CH.sub.3 H H 4.9-4.4 m (1H); 4.2 q (2H); 4.0-3.1 m+ s (7H); 2.4 s (3H);     2.3 t (2H);1.9-1.4 m (9H); 1.2 t (3H)  494 1 H C.sub.2 H.sub.5 " C.sub.2     H.sub.5 H H 4.9-4.4 m (1H); 4.2 q (2H); 4.0-3.1         m + s (9H); 2.3     t (2H); 1.9-1.4 m         (9H); 1.2 t (3H); 1.0 t (3H) 495 1 H C.sub.2     H.sub.5 " CH(CH.sub.3).sub.2 H H 4.9-4.4 m (1H); 4.2 q (2H); 4.0-3.1         m + s (8H); 2.3 t (2H); 1.9-(9H)         1.2 t (3H); 0.9 d (6H) 496     1 H C.sub.2 H.sub.5 " CH.sub.3 H CH.sub.3 4.9-4.4 m (1H); 4.2 q (2H);     4.0-         2.9 m + s (8H); 2.3 s (3H); 1.9-1.4         m (9H); 1.2 t     (3H); 1.0 d (3H)

I claim:
 1. A compound of the formula I ##STR132## in which n is a wholenumber between 0 and 3 inclusive;R¹ and R^(1'), being the same ordifferent, are hydrogen; alkyl or alkenyl having 1-8 C atoms; phenyl orbenzyl, each unsubstituted or monosubstituted by methyl, halogen,methoxy or nitro; R² and R³ together with the C and N atoms carryingthem form an octahydroindole ring system, which is unsubstituted,monosubstituted or disubstituted by hydroxyl, alkoxy having 1-3 C atoms,alkyl having 1-3 C atoms or phenyl; R⁴ is hydrogen; alkyl, alkenyl,alkadienyl, alkinyl, alkeninyl or alkadiinyl having 1-8 C atoms;cycloalkyl having 3-6 C atoms; phenyl, benzyl, phenethyl orphenylpropyl, each of which is unsubstituted, monosubstituted ordisubstituted by halogen, hydroxyl, acetoxy, carboxy, carboxamido,sulfonamido, nitro, methyl, ethyl, methoxy, ethoxy or methylenedioxy; R⁵is hydrogen; alkyl having 1-5 C atoms; hydroxyl or alkoxy having 1-3 Catoms; R⁶ is hydrogen; alkyl having 1-12 C atoms; cycloalkyl having 3-12C atoms; alkenyl having 2-12 C atoms; phenyl or naphthyl, each of whichis unsubstituted, monosubstituted or disubstituted by halogen, hydroxyl,acetoxy, carboxy, carboxamido, sulfonamido, nitro, methyl, ethyl,methoxy, ethoxy or methylenedioxy; alkyl having 1-6 C atoms, which ismonosubstituted by halogen, hydroxyl, alkoxy having 1-3 C atoms,phenoxy, amino, dialkylamino having 1-6 C atoms, alkanoylamino having1-3 C atoms, mercapto, alkylthio having 1-3 C atoms, phenylthio,phenylsulfinyl, phenylsulfonyl, phenyl, biphenylyl, or naphthyl, thephenyl or naphthyl each being unsubstituted, monosubstituted ordisubstituted by halogen, methyl, ethyl, methoxy, ethoxy, nitro, amino,methylamino, dimethylamino, acetylamino, cyano, methylenedioxy orsulfonamido; heteroaryl selected from the group consisting of pyridyl,thienyl, indolyl, benzothienyl, imidazolyl, pyrazolyl and thiazolyl,said heteroaryl being unsubstituted, monosubstituted or disubstituted byhalogen, methyl, ethyl, methoxy, ethoxy, nitro, amino, methylamino,dimethylamino, acetylamino, cyano, methylenedioxy, sulfonamido orphenyl; or physiologically tolerable salts thereof.
 2. A compound of theformula I as claimed in claim 1, wherein the substituentsn denotes 0 to2, R¹ and R^(1') denote hydrogen, alkyl or alkenyl having 1 to 4 Catoms, or benzyl optionally substituted in the phenyl nucleus by methyl,halogen, methoxy or nitro; R⁴ denotes hydrogen, straight-chain orbranched alkyl, alkenyl or alkinyl having 1 to 5 C atoms, cycloalkylhaving 3 to 6 C atoms, phenyl, benzyl or phenethyl; R⁵ denotes hydrogen,methyl, ethyl, hydroxyl, methoxy or benzyl; R⁶ denotes hydrogen, alkylhaving 1 to 8 carbon atoms or phenyl which can be monosubstituted ordisubstituted by methyl, halogen, methoxy, acetoxy or nitro; or alkylwith 1-4 C atoms substituted by halogen, hydroxyl, methoxy, ethoxy,phenoxy, amino, methylamino, dimethylamino, anilino, acetylamino,benzamido, mercapto, phenylthio, phenylsulfinyl, phenylsulfonyl; phenyl,which is optionally monosubstituted or disubstituted by halogen, methyl,ethyl, methoxy, ethoxy, nitro, amino, methylamino, dimethylamino,acetylamino, cyano, methylenedioxy or sulfonamido, biphenylyl, orheteroaryl which is optionally substituted by halogen, methyl, methoxyand phenyl.
 3. A compound of the formula I as claimed in claim 1,wherein the substituentn denotes 0 or 1, R¹ and R^(1') denote hydrogen,methyl, ethyl, n-butyl, t-butyl, benzyl or p-nitrophenyl, R⁴ denotesmethyl, ethyl, n-propyl, n-butyl, isopropyl, isobutyl, cyclopropyl,cyclobutyl, allyl, butenyl, propargyl, butinyl or tert.-butyl; R⁵denotes hydrogen, methyl or benzyl; R⁶ denotes hydrogen, straight-chainor branched alkyl or alkenyl having 1 to 6 C atoms or cycloalkyl having3 to 6 C atoms; or alkyl having 1 to 3 C atoms which is substituted byphenoxy, ethoxy, methoxy, dimethylamino, anilino, benzamido, phenylthio,phenylsulfinyl, phenylsulfonyl; phenyl which is optionallymonosubstituted or disubstituted by halogen, methyl, methoxy, nitro,amino, methylamino, dimethylamino, acetylamino, cyano or methylenedioxy,biphenylyl; or heteroaryl which is optionally substituted by chlorine,methyl, methoxy or phenyl.
 4. A compound of the formula I as claimed inone of claim 1, 2 or 3, wherein the carbon atom which carries thesubstituent R³ has the S-configuration.
 5. A compound of the formula Ias claimed in claim 1, wherein n denotes 1, R¹ denotes hydrogen, R² andR³, together with the C and N atoms carrying them, denote theoctahydroindole system, R⁴ denotes ethyl, R⁵ denotes hydrogen and R⁶denotes β-phenylethyl.
 6. A compound as in claim 2, wherein the carbonatom which carries the substituent R³ has the S-configuration.
 7. Acompound of the formula as in claim 3, wherein the carbon atom whichcarries the substituent R³ has the S-configuration.
 8. A compound as inclaim 5, wherein the carbon atom which carries the substituent R³ hasthe S-configuration. 9.(2S)-[N-ethyl-N-(4-phenyl-2R-carboethoxybutyl)-carbamoyl]-cis-endo-octahydroindole-2-carboxylicacid.
 10. Hypotensive composition containing a hypotensively effectiveconcentration of a compound defined in claim 1 and a carrier therefor.11. Hypotensive dosage unit containing from about 20 mg. to about 3 g.of a compound defined in claim
 1. 12. Hypotensive dosage unit containingfrom about 50 mg. to about 1 g. of a compound defined in claim
 1. 13. Amethod of treatment which comprises administering to a patient sufferingfrom hypertension a hypotensively effective amount of a compound definedin claim 1.